Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

An in Vitro Evaluation of the Antimicrobial Effectiveness of Alginate-Based Metronidazole Gel Against Aggregatibacter Actinomycetemcomitans

Authors
Martina Amalia, Irma Ervina, Hakim Bangun
Corresponding Author
Martina Amalia
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.41How to use a DOI?
Keywords
metronidazole gel, alginate, Aggregatibacter actinomycetemcomitans
Abstract
This study was to analyze the effect of alginate based metronidazole gel in inhib-iting A. actinomycetemcomitans bacteria growth with in vitro evaluation. Algi-nate-based gel used in this study contains metronidazole 15%, 25%, and 25% metronidazole non-alginate based gel as a comparison. The bacteria used were a pure culture of A. actinomycetemcomitans (ATCC 29522), cultured in Tryptic Soy Agar (TSA) media. Bacteria test was done by placing the metronidazole gel into TSA media that contained bacteria which was put on the disc paper with the aid of sterile tweezers, and 100µl of gel metronidazole was dripped on the disc paper after that TSA media was incubated at 370 C for 24 hours. Measurement of the inhibit zone diameter was observed daily for three days using callipers. The average diameter of inhibition zone of 15%, 25% metronidazole alginate-based gel and 25% metronidazole non-alginate based gel towards A. actinomycetem-comitans were 15.33 mm, 16.67 mm and 15.33 mm. There was no significant dif-ference between day one and three on 15% and 25% alginate based metronida-zole gel, except for non-alginate-based metronidazole gel there was a significant difference between day 1, 2 and 3. The result suggested that 15%, 25% alginate based and 25% metronidazole non-alginate-based metronidazole gel has a strong influence towards A. actinomycetemcomitans bacteria.
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Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.41How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Martina Amalia
AU  - Irma Ervina
AU  - Hakim Bangun
PY  - 2018/05
DA  - 2018/05
TI  - An in Vitro Evaluation of the Antimicrobial Effectiveness of Alginate-Based Metronidazole Gel Against Aggregatibacter Actinomycetemcomitans
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.41
DO  - https://doi.org/10.2991/idsm-17.2018.41
ID  - Amalia2018/05
ER  -