Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)

Session: Pharmacy: research, industry and education

29 articles
Proceedings Article

Ways of Medication Administration Improving for Treating Pregnant Women with Acute Respiratory Viral Infection

Irina Spichak, Yuliia Murashko, Olga Vladimirova
The article presents the results of the research aimed at Medication Administration improving for pregnant woman with acute respiratory viral. During this social research a medical and social portrait of woman with acute respiratory viral was developed, the analysis of satisfaction and preferences in...
Proceedings Article

Marketing Analysis of Additional Services Provided by Pharmacies

Irina Spichak, Natalia Grigorenko, Ekaterina Boyko, Alina Ivashchenkova
The article presents the concept of marketing analysis of the additional services provided in pharmacies in the city of Belgorod. The authors carried out the assessment of customers' satisfaction with the quality of the additional services provided in the pharmacies in the city of Belgorod. Also the...
Proceedings Article

Improvement of Drug Supply for Women with Climacteric Disorders

Irina Spichak, Tatyana Babanina, Irina Zhirova
The article presents the results of improving the drug supply for women with menopausal disorders at the regional level. A sociological study of women with climacteric disorders as a consumer of pharmaceutical care has been conducted. Marketing analysis of the Russian and regional pharmaceutical markets...
Proceedings Article

Optimization of Drug Provision for Children with Diseases of Autonomic Nervous System under Inpatient Treatment

Irina Spichak, Olga Vladimirova, Irina Zhirova
The article presents the results of the optimization of the drug supply for children with disorders of the autonomic nervous system (ANS) under inpatient treatment at the regional level; a socio-demographic portrait of a child affected with autonomic dysfunction syndrome has been developed; a pharmacoeconomic...
Proceedings Article

Marketing Analysis of the Pharmaceutical Market of Drugs for Weight Disorder Treatment

Alena Spichak, Galina Glembotskaya, Galina Varenykh, Irina Zhirova
The article presents the results of a marketing research of the Russian pharmaceutical market of drugs for the treatment of weight disorders - overweight and underweight. Macrocontours have been developed, the main trends in market formation have been identified.
Proceedings Article

Search of New Opportunities of Pharmacological Protection at the Early Stages of a Non-Alcoholic Fatty Liver Disease Associated With Obesity and Metabolic Syndrome

Elena Zhilyakova, Tatyana Golivets, Zoya Tsvetkova, Diana Dubonosova
This article provides the rationale for the pharmacological correction of non-alcoholic fatty liver disease. This is due to the fact that non-alcoholic steatohepatosis of the liver is a slowly progressing disease. Most often, non-alcoholic steatohepatosis progresses to non-alcoholic steatohepatitis,...
Proceedings Article

Development of Methods For Quantitative Determination of Polyphenols in Grass Pentaphylloides Fruticosa (L.) O. Schwarz.

Elena Zhilyakova, Oleg Novikov, Dmitriy Pisarev, Liliya Zolotareva
The purpose of this study was to develop a method of quali-tative and quantitative assessment of biologically active sub-stances of P. fruticosa L. herb. As object of study was used P. fruticosa L. herb. We used the method of high performance liquid chromatography in reversed-phase variant. As a result...
Proceedings Article

Prospects of Using Freons as Extractants of Curcuma Longa L. Root Essential Oil

Elena Zhilyakova, Oleg Novikov, Dmitriy Pisarev, Nikolay Boyko, Konstantin Nikitin
the purpose of the present study was a comparative study of the ability of some freons to extract the essential oil of the roots of C. longa L. and to provide optimal conditions for its analy-sis. The dried, crushed roots of C. longa L. were used as raw materials (country of origin - Uganda). Methoxynonafluorobu-tane...
Proceedings Article

Validation of Quantitative Determination Methods for Fexofenadine Hydrochloride and Cyanocobalamine in Separate Ophthalmological Dosage Forms Using UV-Spectrophotometry Instrumentation

Elena Zhilyakova, Nabel Mohamad, Abdulhadi Bakri, Denis Naplekov, Diana Martseva
Aim of this study is validation of quantitative determination methods for Fexofenadine hydrochloride, Cyanocobalamine in separate ophthalmological dosage forms using UV-spectrophotometry instrumentation. Assay tests of the studied ophthalmological dosage forms were carried out using the APIs and reagents...
Proceedings Article

Classification and Systematics of Medical Clay

Alexander Bondarev, Elena Zhilyakova, Nina Bondareva, Daria Fadeeva
The aim of the work is to develop classification and systematics of Medical Clays. Tasks: to conduct screening marketing study of the pharmaceutical market of medical clays in Russia and neighboring countries; to develop classification and systematics of Medical Clays with their characteristics. The...
Proceedings Article

A New Approach To Description Of Equilibrium State In The Extraction System Of Vegetal Raw Material-Extractant

Nikolay Boyko, Elena Zhilyakova, Oleg Novikov, Dmitriy Pisarev, Alexander Bondarev, Denis Naplekov, Diana Martceva
Aim of this study is the theoretical justification and experimental confirmation of new approach to description of equilibrium state in extraction system vegetal raw material-extractant. In framework of this study the milled raw material was used containing the particles sized 0,1-0,5 mm: roots and rhyzomes...
Proceedings Article

Study of Perfluoro Organic Solvent Novec 1230 Extraction Properties in Regards to Low Polar Substances from Plant Raw Materials

Nikolay Boyko, Elena Zhilyakova, Oleg Novikov, Dmitriy Pisarev, Alexander Bondarev, Zoja Tsvetkova, Elena Timoshenko, Tatjana Pankrusheva
The purpose of this work is an experimental study of the extraction properties of Novec 1230 perfluoro organic solvent in regards to various types of low-polar biologically active substances from plant materials. For the study purposes, we used the following ground plant raw materials with particle size...
Proceedings Article

The Effect of the Bicyclononan Derivative on the Conditioned Reflex of Passive Avoidance in Rats with Cerebral Ischemia

Galina Brkich, Natalia Pyatigorskaya, Andrey Nedorubov, Olga Filippova, Oleg Zyryanov
The aim of this study was to develop the effect of substance Z–109 - a bicyclononan derivative, presumably belonging to the class of ampakines on the memory of rats undergoing cerebral ischemia. The evaluation of mnestic functions was carried out on the model of the conditioned passive avoidance reflex....
Proceedings Article

Pharmaceutical Composition Based on Two Innovative Chitosan-Containing Substances – The Chitosan-Chymopsin Complex and the Chitosan-Miramistin Complex – for Production of a Finished Dosage Form for the Treatment of Infected Wounds of Various Origins

Liliana Brkich, Tatiana Salnikova, Natalia Pyatigorskaya, Galina Brkich, Vasily Belyaev
Developed pharmaceutical composition based on two innovative chitosan-containing substances: the chitosan-chymopsin complex and the chitosan-miramistin complex, for the treatment of infected wounds in gel dosage form for external use has four types of pharmacological effects - necrolytic, antimicrobial,...
Proceedings Article

Validation of the analytical method for Repaglinide residual amount determination on the surfaces of cleanrooms and pharmaceutical equipment by means of UV spectrophotometry

Andrey Bursakov, Nasima Abdrazakova, Elena Kryazheva, Olga Knysh, Ekaterina Vaseva, Ivan Glukharev
During the drugs production, one of the most important requirements of good manufacturing practice (GMP) is the equipment cleaning from active pharmaceutical substance residues, which has to be carried out to prevent cross-contamination in case of switching from the production of one drug to another....
Proceedings Article

Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid

Elena Chuyan, Marina Ravaeva, Igor Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, Elena Birukova
scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3- (1,2,4-Triazolyl) Propane And 11-Hydroxy-1,1-Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex...
Proceedings Article

Methodical Approach to Carrying out a Multi-Aspect Examination of Pharmaceutical Products

Yuliya Dereglazova, Irina Spichak, Elena Kaliuzhnaya
The article presents the developed methodological approach to the technology of conducting a multi-aspect examination of the range of pharmaceutical products. This approach may be of interest for optimizing the prescription of pharmaceutical products by doctors in medical organizations during the pharmacotherapy...
Proceedings Article

Accumulation of artificial and natural radionuclides in medicinal plant material in the Central Black Soil Region of Russia

Nina Dyakova, Sergey Gaponov, Alexey Slivkin, Elena Chupandina
Levels of strontium-90, cesium-137, thorium-232, potassium-40, and radium-226 were studied in medicinal plant species, along with the accumulation of these elements from soils. Medicinal plant raw materials from ten plant species were collected in 36 sampling points in the Voronezh Region. Findings...
Proceedings Article

Phytochemical Studies and Standardization of Scabiosa Succisa L.

Lyudmila Efremencko, Anastasiya Malyutina, Dmitriy Pisarev, Valentina Scorbach, Nataliya Shestopalova, Valentina Kasakova, Dariya Fadeeva
The aim of this work is phytochemical studies and standardization of Scabiosa succisa L. By reverse phase high performance liquid chromatography of ethanol extract substances belonging to polyphenolic compounds were found, among which hydroxycinnamic acids predominate. Chlorogenic acid and flavonoid...
Proceedings Article

Rationalization of the range of medicines for the treatment of patients with diabetes (on the example of the Tyumen region)

Alexandra Egorova, Olga Knysh, Ksenia Vikulova, Yulia Rodina, Yulia Latypova, Viktoria Melnikova
The significant importance for preventive measures of early disability of patients with diabetes belongs to drug treatment of underlying and concomitant disease, that must be provided by high –value medicines timely and in full volume. In this regard, it is important to find ways to improve the quality...
Proceedings Article

Research of the Main Components of Risk Management in Pharmacy

Olena Ievtushenko, Irina Zhirova, Irina Spichak
A market economy characterized by existing of uncertainty and the possibility of choosing one or more development directions for the pharmaceutical market subjects causes risk situations. The reasons for their occurrence are usually the company affiliation, its size, form of ownership, legal status,...
Proceedings Article

Methods of Extraction of Medicinal Vegetable Raw Materials in Phytosubstances Technology

Irina Kaukhova, Victor Weinstein, Marina Burakova, Mariya Aroyan, Ekaterina Novikova
The article discusses the technology of obtaining phytosubstances using modern methods of extraction of medicinal plant materials: ultrasonic extraction, two-phase extraction. On the example of various types of plant materials, a comparative analysis was carried out and the advantages and disadvantages...
Proceedings Article

Audit of the Production of Sterile Medicines for Compliance with the Requirements of the Draft EU GMP Annex 1 with Risk Analysis

Artemii Kodash, Anna Basevich, Tatiana Bitkina, Elena Smirnova, Irina Kaukhova
The role of the PIC/S organization in the pharmaceutical industry was noted, the main aspects and place of inspection activities in the production of medicines were determined, the general classification of incompliances, as well as the main methods and tools for risk assessment were considered. An object...
Proceedings Article

Optimization of a Method for Obtaining and Determination of Carotenoids in Tambukan Mud

Dmitriy Kompantsev, Anna Chakhirova, Taisiya Gutnova
Therapeutic sulphide silt mud from Tambukan lake has been formed for a long period of time. Balneological value of silt mud from that specific lake is high because of high level of ferrous sulphides and water-soluble salts in it’s content, including recognized as therapeutically active bromine and boric...
Proceedings Article

Development of a Derivative of 1,4-Dihydropyridine Gels Using Solid Dispersion Technique

Ivan Krasnyuk (Jr.), Viktoriya Grikh, Ivan Krasnyuk, Anastasiya Belyatskaya, Olga Stepanova, Vladimir Beketov, Galina Varenykh
A method has been developed for obtaining samples of a derivative of 1,4-dihydropyridine-nifedipine gels using the solid dispersion technique. A quality assessment of the obtained soft dosage forms has been performed. The effectiveness of the proposed technique for obtaining nifedipine gels has been...
Proceedings Article

Study of Antimicrobial Activity of the Callus Tissue Salvia Pratensis L. (Lamiaceae) In Vitro

Elena Maslova, Tatyana Glodik, Valeria Semykina, Natalya Gulya, Tatyana Perelygina
In this paper, we studied the antimicrobial activity of callus tissue Salvia pratensis L. obtained in vitro against Escherichia coli and Staphylococcus aureus. The most effective sterilizing agents for disinfection of plant explants with their introduction into in vitro culture were selected. The composition...
Proceedings Article

Determination of Antibacterial Activity of Artemísia Absínthium L. (Asteraceae) Extracts

Elena Maslova, Valeria Semykina, Tatyana Glodik, Tatyana Perelygina, Margarita Petrosyan
In this study, plant extracts of Artemisia absinthium L. were produced. Herbal extracts from leaves and flowers were evaluated for antibacterial activity against Escherichia coli and Staphylococcus aureus. As a result, it was found that plant extracts from Artemisia asbinthium flowers have the greatest...
Proceedings Article

Development of Treatment and Prophylactic Means with Selenium Nanoparticles on the Basis of Mineral Water of the Krasnoarmeysk Source for Application in Balneology

Madina Nastueva, Dmitry Kompantsev, Gayane Sagradyan, Igor Privalov, Asya Airapetova, Alexander Serov
The purpose of the study is development technology of receiving mineral waters with nanoparticles of selenium and studying of their stability. The studied samples — the concentrated solution of nanoparticles of selenium contens selenium about 1,4 mg/ml, mineral water of the Krasnoarmeysky source. The...
Proceedings Article

Study and Modeling the Influence of a Solvent on Extraction of Eugenol from Laurus Nobilis L. Leaves

Valentina Radyukova, Nikolay Boyko, Elena Zhilyakova, Zoja Tsvetkova, Diana Martceva, Anastasia Malyutina, Valentina Kasakova, Daria Fadeeva, Ghadeer Balloul
this paper presents the results of a study and modeling of the influence of the solvent’s dielectric constant on the extraction of eugenol from the Laurus nobilis L leaves. The aim of this work is to study the effect of the solvent on the extraction of eugenol from the leaves of Laurus nobilis L., to...