Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster
- H.L. Wang, Z.S. Zhang, Z.O. Sun, H. Wang, N. Ma, H. Wang
- Corresponding Author
- H.L. Wang
Available Online March 2016.
- https://doi.org/10.2991/meep-15.2016.49How to use a DOI?
- rosemary extract; drosophila melanogaster; anti-aging; antioxidation
- Rosemary (Rosmarinus officinalis L.) has always known a versatile, aromatic herb and addition to being used as a food flavoring is also known medicinally for its powerful antioxidant activity, antibacterial and hepatoprotective properties. In this study we examined the effects of rosemary iextract on the lifespan and aging in Drosophila melanogaster against high-fat induced oxidative injury, and found that it responded to rosemary extract with an increased lifespan and reduced MDA content during aging. We found that lifespan extension by rosemary extract was attributed to its increasing the activity of SOD, CAT and decreasing the content of MDA. Moreover, Realtime-PCR analysis showed that the gene expression of SOD, and CAT was enhanced, in contrast MTH was significantly reduced. In conclusion, these results suggest that the antioxidant and antiaging effect of rosemary extract may, at least in part, be due to its interactions with endogenous antioxidant protective enzymes including SOD and CAT.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - H.L. Wang AU - Z.S. Zhang AU - Z.O. Sun AU - H. Wang AU - N. Ma AU - H. Wang PY - 2016/03 DA - 2016/03 TI - Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster BT - International Conference on Materials Chemistry and Environmental Protection 2015 PB - Atlantis Press SN - 2352-541X UR - https://doi.org/10.2991/meep-15.2016.49 DO - https://doi.org/10.2991/meep-15.2016.49 ID - Wang2016/03 ER -