In vivo Evaluation of Microemulsion-Based Transdermal Gel of Coumarins from Cortex Daphnes

DOI

10.2991/meic-15.2015.377How to use a DOI?

Keywords

coumarins; Cortex daphnes; microemulsion; pharmacokinetic; transdermal delivery

Abstract

Objetive The aim of the present study was to investigate the pharmacokinetics of coumarins from cortex daphnes (CCD) in a microemulsion (ME) gel transdermal delivery system with a newly developed HPLC method. Methods The pharmacokinetics of the microemulsion containing CCD was studied in rabbits with the established HPLC method. Results The results showed that among the three index compounds of CCD, the daphnin and daphne-8-O- -D-glucoside from ME gel presented significant higher AUC(0- ) and Cmax compared to the conventional preparation (CP), while daphnetin showed similar AUC(0- ) and higher Cmax compared to the latter. Conclusion Hence, the established HPLC method was suitable to analyze the CCD components in ME and the ME gel could be a promising transdermal delivery system for CCD.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jinli Deng
AU  - Xia Feng
AU  - Li Ma
AU  - Feng Han
AU  - Xingcui Qu
AU  - Yafei Wang
PY  - 2015/04
DA  - 2015/04
TI  - In vivo Evaluation of Microemulsion-Based Transdermal Gel of Coumarins from Cortex Daphnes
BT  - Proceedings of the 2015 International Conference on Mechatronics, Electronic, Industrial and Control Engineering
PB  - Atlantis Press
SP  - 1649
EP  - 1653
SN  - 2352-5401
UR  - https://doi.org/10.2991/meic-15.2015.377
DO  - 10.2991/meic-15.2015.377
ID  - Deng2015/04
ER  -