Proceedings of the 2016 2nd International Conference on Materials Engineering and Information Technology Applications (MEITA 2016)

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Effects of Radix Total Glucosides of Paeonia on the Endoplasmic Reticulum Stress and Macrophage Recruitment on Diabetic Cardiomyopathy Rats

Authors
Hongyu Kang, Ximin Liu, Yaping Zheng, Chunjie Liu, Jingli Ren
Corresponding Author
Hongyu Kang
Available Online February 2017.
DOI
10.2991/meita-16.2017.82How to use a DOI?
Keywords
Ischemia Reperfusion; Total Glucosides of Paeonia; Apoptosis; Wnt3a; P-GSK-3; -Catenin
Abstract

Aim To investigate the effects of Total glucosides of paeonia (TGP) on on myocardial ischemia reperfusion rats and the role of Wnt/ -catenin signaling pathway was also investigated. Methods Sprague-Dawley rats were randomly divided into 5 groups: sham operation group, IR group, TGP low-dose group(i.g.50mg/kg), TGP middle-dose group(i.g.100mg/kg), TGP high-dose group(i.g.200mg/kg). The level of myocardial Wnt3a GSK-3 (p-GSK-3 ) -catenin express were measureed by western blot. Myocardial infarction size was detected by TTC staining. The apoptotic cardiomyocytes were assessed through TUNEL .Results Compared with IR group, TGP can increase LVSP, LVEDP, +dp/dtmax, LVEF. The expressions of Wnt3a,GSK-3 (p-GSK-3 ), -catenin, the apoptotic index and myocardial infarction size were lower in the TGP group than those in I/R group ( P < 0. 01).Conclusion The protective effect of TGP on myocardial ischemia reperfusion rats is obviously, Wnt/ -catenin signaling pathway maybe involved in the mechanism.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 2nd International Conference on Materials Engineering and Information Technology Applications (MEITA 2016)
Series
Advances in Engineering Research
Publication Date
February 2017
ISBN
10.2991/meita-16.2017.82
ISSN
2352-5401
DOI
10.2991/meita-16.2017.82How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Hongyu Kang
AU  - Ximin Liu
AU  - Yaping Zheng
AU  - Chunjie Liu
AU  - Jingli Ren
PY  - 2017/02
DA  - 2017/02
TI  - Effects of Radix Total Glucosides of Paeonia on the Endoplasmic Reticulum Stress and Macrophage Recruitment on Diabetic Cardiomyopathy Rats
BT  - Proceedings of the 2016 2nd International Conference on Materials Engineering and Information Technology Applications (MEITA 2016)
PB  - Atlantis Press
SP  - 396
EP  - 400
SN  - 2352-5401
UR  - https://doi.org/10.2991/meita-16.2017.82
DO  - 10.2991/meita-16.2017.82
ID  - Kang2017/02
ER  -