Synthesis of 1-(4-bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one
- 10.2991/mmme-16.2016.91How to use a DOI?
- 1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one; Pyridin-4-ol; Synthesis
1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from pyridin-4-ol (7) and 4-bromo-2-fluoroaniline through five steps including nitration, chlorination, N-alkylation, reduction and condensation. The structures of the compound 8 was confirmed by 1H NMR spectrums and target compound 1 confirmed by Mass spectra.
- © 2016, the Authors. Published by Atlantis Press.
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Cite this article
TY - CONF AU - Linxiao Wang AU - Wei Lu AU - Zhen Xiao AU - Min Zhou AU - Jiqing Li AU - Shan Xu PY - 2016/10 DA - 2016/10 TI - Synthesis of 1-(4-bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one BT - Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering PB - Atlantis Press SP - 399 EP - 401 SN - 2352-5401 UR - https://doi.org/10.2991/mmme-16.2016.91 DO - 10.2991/mmme-16.2016.91 ID - Wang2016/10 ER -