Synthesis of 1-(4-bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one

DOI

10.2991/mmme-16.2016.91How to use a DOI?

Keywords

1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one; Pyridin-4-ol; Synthesis

Abstract

1-(4-Bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from pyridin-4-ol (7) and 4-bromo-2-fluoroaniline through five steps including nitration, chlorination, N-alkylation, reduction and condensation. The structures of the compound 8 was confirmed by 1H NMR spectrums and target compound 1 confirmed by Mass spectra.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Linxiao Wang
AU  - Wei Lu
AU  - Zhen Xiao
AU  - Min Zhou
AU  - Jiqing Li
AU  - Shan Xu
PY  - 2016/10
DA  - 2016/10
TI  - Synthesis of 1-(4-bromo-2-fluorophenyl)-1,3-dihydro-2H-imidazo[4,5-c] pyridin-2-one
BT  - Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering
PB  - Atlantis Press
SP  - 399
EP  - 401
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmme-16.2016.91
DO  - 10.2991/mmme-16.2016.91
ID  - Wang2016/10
ER  -