Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile
- 10.2991/mmme-16.2016.92How to use a DOI?
- 2-(4-nitrobenzylidene)malononitrile; 3-(4-nitrophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; 3-(4-aminophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis
3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to syn-thesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially availa-ble 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malono-nitrile).
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Shanshan Hou AU - Yuanzhang Zhou AU - Wei Lu AU - Jiaqian Han AU - Ziwei Zhang AU - Shan Xu PY - 2016/10 DA - 2016/10 TI - Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile BT - Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering PB - Atlantis Press SP - 402 EP - 404 SN - 2352-5401 UR - https://doi.org/10.2991/mmme-16.2016.92 DO - 10.2991/mmme-16.2016.92 ID - Hou2016/10 ER -