Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile

DOI

10.2991/mmme-16.2016.92How to use a DOI?

Keywords

2-(4-nitrobenzylidene)malononitrile; 3-(4-nitrophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; 3-(4-aminophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis

Abstract

3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to syn-thesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially availa-ble 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malono-nitrile).

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Shanshan Hou
AU  - Yuanzhang Zhou
AU  - Wei Lu
AU  - Jiaqian Han
AU  - Ziwei Zhang
AU  - Shan Xu
PY  - 2016/10
DA  - 2016/10
TI  - Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile
BT  - Proceedings of the 2016 4th International Conference on Mechanical Materials and Manufacturing Engineering
PB  - Atlantis Press
SP  - 402
EP  - 404
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmme-16.2016.92
DO  - 10.2991/mmme-16.2016.92
ID  - Hou2016/10
ER  -