Proceedings of the 2017 International Conference on Material Science, Energy and Environmental Engineering (MSEEE 2017)

Effects of Ultrasound on Behavior and Dopamine Content in Striatum of Parkinson's Disease Model Mouse

Authors
Weiwei Wang, Li Li, Wei Wu, Wanlin Zhang, Ying Gao, Chen Chen
Corresponding Author
Weiwei Wang
Available Online August 2017.
DOI
10.2991/mseee-17.2017.34How to use a DOI?
Keywords
ultrasound, PD, behavior, DA
Abstract

In this research, we established a MPTP mouse model of PD, then ultrasound was used to stimulate the model to explore the effects of ultrasound on behavior and dopamine content in striatum. With the prolongation of ultrasonic stimulation time, the delay of observation time, the amount of DA in the striatum of the ultrasonic treatment group was increasing. Using ultrasound with a frequency of 1 MHz at an intensity of 0.3W/cm2 over 15min for 1d, 5d or 10d respectively, in each group, there was a significant difference in the content of DA in the striatum compare to PD observation group at the same observation time(P<0.05). Especially, the DA content in the striatum of the mice treated with the ultrasound for 10 d was not statistically significant compared with the control group(P>0.05). Combined with the results of climbing test and open field test and general behavioral changes, the difference between ultrasound group and PD group reached a significant level (P<0.05). In summary, ultrasound can increase the DA content in the brain and improve the motor capacity of PD model. It suggests that ultrasound may be a safe and effective new method of PD treatment.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2017 International Conference on Material Science, Energy and Environmental Engineering (MSEEE 2017)
Series
Advances in Engineering Research
Publication Date
August 2017
ISBN
10.2991/mseee-17.2017.34
ISSN
2352-5401
DOI
10.2991/mseee-17.2017.34How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Weiwei Wang
AU  - Li Li
AU  - Wei Wu
AU  - Wanlin Zhang
AU  - Ying Gao
AU  - Chen Chen
PY  - 2017/08
DA  - 2017/08
TI  - Effects of Ultrasound on Behavior and Dopamine Content in Striatum of Parkinson's Disease Model Mouse
BT  - Proceedings of the 2017 International Conference on Material Science, Energy and Environmental Engineering (MSEEE 2017)
PB  - Atlantis Press
SP  - 181
EP  - 186
SN  - 2352-5401
UR  - https://doi.org/10.2991/mseee-17.2017.34
DO  - 10.2991/mseee-17.2017.34
ID  - Wang2017/08
ER  -