Establishing a cohort in a developing country: Experiences of the diabetes-tuberculosis treatment outcome cohort study

Fatima Mukhtar; Zahid A. Butt

doi:10.1016/j.jegh.2017.08.003

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Volume 7, Issue 4, December 2017, Pages 249 - 254

Establishing a cohort in a developing country: Experiences of the diabetes-tuberculosis treatment outcome cohort study

Authors

Fatima Mukhtar^a^{, b}^{, *}^,fatimamukhtar@doctor.com, Zahid A. Butt^c^{, d}

^aHealth Services Academy, Islamabad, Pakistan

^bDepartment of Community Medicine, Lahore Medical & Dental College, Lahore, Pakistan

^cDepartment of Epidemiology & Biostatistics, Health Services Academy, Islamabad, Pakistan

^dSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada

^*Corresponding author at: 7 Aziz Bhatti Road, Lahore, Cantt., Lahore, Pakistan.

Corresponding Author

Fatima Mukhtarfatimamukhtar@doctor.com

Received 12 December 2016, Revised 8 August 2017, Accepted 12 August 2017, Available Online 24 August 2017.

DOI: 10.1016/j.jegh.2017.08.003 How to use a DOI?
Keywords: Cohort study; Pakistan; Diabetes; Tuberculosis
Abstract: Background: Prospective cohort studies are instrumental in generating valid scientific evidence based on identifying temporal associations between cause and effect. Researchers in a developing country like Pakistan seldom undertake cohort studies hence little is known about the challenges encountered while conducting them. We describe the retention rates among tuberculosis patients with and without diabetes, look at factors associated with loss to follow up among the cohort and assess operational factors that contributed to retention of cohort.

Methods: A prospective cohort study was initiated in October 2013 at the Gulab Devi Chest Hospital, Lahore, Pakistan. We recruited 614 new adult cases of pulmonary tuberculosis, whose diabetic status was ascertained by conducting random and fasting blood glucose tests. The cohort was followed up at the 2nd, 5th and 6th month while on anti-tuberculosis therapy (ATT) and 6 months after ATT completion to determine treatment outcomes among the two groups i.e. patients with diabetes and patients without diabetes.

Results: The overall retention rate was 81.9% (n = 503), with 82.3% (93/113) among patients with diabetes and 81.8% (410/501) among patients without diabetes (p = 0.91). Age (p = 0.001), area of residence (p = 0.029), marital status (p = 0.001), educational qualification (p = <0.001) and smoking (p = 0.026) were significantly associated with loss to follow up. Respondents were lost to follow up due to inability of research team to contact them as either contact numbers provided were incorrect or switched off (44/111, 39.6%).

Conclusion: We were able to retain 81.9% of PTB patients in the diabetes tuberculosis treatment outcome (DITTO) study for 12 months. Retention rates among people with and without diabetes were similar. Older age, rural residence, illiteracy and smoking were associated with loss to follow up. The study employed gender matched data collectors, had a 24-h helpline for patients and sent follow up reminders through telephone calls rather than short messaging service, which might have contributed to retention of cohort.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 7 - 4
Pages: 249 - 254
Publication Date: 2017/08/24
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2017.08.003 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Fatima Mukhtar
AU  - Zahid A. Butt
PY  - 2017
DA  - 2017/08/24
TI  - Establishing a cohort in a developing country: Experiences of the diabetes-tuberculosis treatment outcome cohort study
JO  - Journal of Epidemiology and Global Health
SP  - 249
EP  - 254
VL  - 7
IS  - 4
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2017.08.003
DO  - 10.1016/j.jegh.2017.08.003
ID  - Mukhtar2017
ER  -

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