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Volume 1, Issue 1, February 2020, Pages 77 - 84

Phenolic Extract from Sonchus oleraceus L. Protects Diabetes-related Liver Injury in Rats through TLR4/NF-κB Signaling Pathway

Authors
Lei Chen1, Xiaoyun Fan1, Xiujun Lin1, Liu Qian1, Gokhan Zengin2, Dominique Delmas3, Paolo Paoli4, Hui Teng1, *, Jianbo Xiao5, *
1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2Department of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey
3INSERM U866 Research Center, Université de Bourgogne, Dijon, France
4Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
5Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China
*Corresponding authors. Email: tenghui850610@126.com; jianboxiao@yahoo.com
Corresponding Authors
Hui Teng, Jianbo Xiao
Received 27 June 2019, Accepted 29 September 2019, Available Online 2 November 2019.
DOI
10.2991/efood.k.191018.002How to use a DOI?
Keywords
Anti-inflammation; in vivo; Sonchus oleraceus; liver injury; NF-κB signaling pathway
Abstract

Sonchus oleraceus Linn. is of great interest in scientific platform because it exhibits significant biological activities. This study investigated the liver protective effects and mechanism of phenolic extract from S. oleraceus (SOL) on Streptozotocin (STZ)-induced diabetic rats. SOL significantly increased both superoxide dismutase activity and glutathione level, while causing a reduction of malondialdehyde level in the liver. Moreover, SOL ameliorates STZ-induced liver function and pathological damages. Diabetic rats fed with S. oleraceus daily for 6 weeks showed significantly decreased levels of tumor necrosis factor alpha and interleukin-1β in the liver. Sonchus oleraceus decreased the expression levels of MyD88, TGF-β, and Toll-Like Receptor (TLR)4 in the liver of diabetic rats. In conclusion, SOL possesses anti-inflammatory activity and suppresses the TLR4/nuclear factor kappa B (NF-κB) p65 signaling pathway.

Copyright
© 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
eFood
Volume-Issue
1 - 1
Pages
77 - 84
Publication Date
2019/11/02
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.191018.002How to use a DOI?
Copyright
© 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Lei Chen
AU  - Xiaoyun Fan
AU  - Xiujun Lin
AU  - Liu Qian
AU  - Gokhan Zengin
AU  - Dominique Delmas
AU  - Paolo Paoli
AU  - Hui Teng
AU  - Jianbo Xiao
PY  - 2019
DA  - 2019/11/02
TI  - Phenolic Extract from Sonchus oleraceus L. Protects Diabetes-related Liver Injury in Rats through TLR4/NF-κB Signaling Pathway
JO  - eFood
SP  - 77
EP  - 84
VL  - 1
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.191018.002
DO  - 10.2991/efood.k.191018.002
ID  - Chen2019
ER  -