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32 articles
Review Article

Bidens pilosa: Nutritional Value and Benefits for Metabolic Syndrome

Tien-Fen Kuo, Greta Yang, Tzung-Yan Chen, Yueh-Chen Wu, Hieu Tran Nguyen Minh, Lin-Shyan Chen, Wen-Chu Chen, Ming-Guang Huang, Yu-Chuan Liang, Wen-Chin Yang
The genus Bidens (Asteraceae) encompasses over 240 different species. One of them is Bidens pilosa L. which is an easy-to-grow perennial, and broadly distributed in tropical and subtropical regions of the world. This plant has been regarded as an edible plant by the Food and Agriculture Organization...
Research Article

Characterizations of a Food Decapeptide Chelating with Zn(II)

Weiwei Fan, Zhenyu Wang, Zhishen Mu, Ming Du, Lianzhou Jiang, Hesham R. EI-Seedi, Cong Wang
Walnut proteins and peptides have been reported to have great zinc-carrying activity. In this study, the decapeptide EPNGLLLPQY (WP-10) derived from walnut protein has been prepared to figure out zinc binding mechanisms and structure–activity relationships. The space-conformation of this peptide has...
Research Article

Food Hygienic Practices and Safety Measures among Street Food Vendors in Zanzibar Urban District

Jamila K. Hassan, Leonard W.T. Fweja
This cross-sectional descriptive study assessed the hygienic and safety measures among street food vendors in the Urban district of Zanzibar. A total of 265 food vendors with stationary food vending units were involved. Data were collected using a structured researcher-administered questionnaire based...
Review Article

miRNAs as Regulators of Antidiabetic Effects of Fucoidans

Chao Zhao, Shanshan Lai, Desheng Wu, Dan Liu, Xiaobo Zou, Amin Ismail, Hesham El-Seedi, Randolph R.J. Arroo, Jianbo Xiao
Pages: 2 - 11
Diabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene expression toward up- or down-regulation. miRNAs have become compelling...
Review Article

Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods

Wataru Aoi, Xiaobo Zou, Jian Bo Xiao, Yoshinori Marunaka
Pages: 12 - 23
Living cells have several mechanisms to avoid acidic conditions created by excess protons. The protons are extruded to the extracellular space via the plasma membrane by various types of transporters such as the Na+/H+ exchanger and monocarboxylate transporters, which hereby contribute to the exclusion...
Review Article

Advances in the Propolis Chemical Composition between 2013 and 2018: A Review

Luka Šturm, Nataša Poklar Ulrih
Pages: 24 - 37
Propolis is a lipophilic sticky substance collected by bees that has been used by humans for centuries. Owing to its healing, antioxidant, and other medicinal properties, its chemical composition has been widely studied. Most pharmacological properties of propolis have been attributed to its phenols...
Review Article

Dietary Flavonoids in the Management of Huntington’s Disease: Mechanism and Clinical Perspective

Haroon Khan, Hammad Ullah, Rosa Tundis, Tarun Belwal, Hari Prasad Devkota, Maria Daglia, Zafer Cetin, Eyup Ilker Saygili, Maria da Graça Campos, Esra Capanoglu, Ming Du, Parsa Dar, Jianbo Xiao
Pages: 38 - 52
Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive loss of neurons, which leads to behavioral systems and mental decline. HD is linked to repeat expansions of cytosine, adenine, and guanine in the Huntingtin (HTT) gene that give rise to mutation, leading to the formation...

Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Li-Shu Wang, Carla Elena Echeveste, Jianhua Yu, Yi-Wen Huang, John Lechner, Ling Mei, Patrick Sanvanson, Martha Yearsley, Chin-Kun Wang, Gary Stoner
Pages: 53 - 60
More than 50% of the world’s population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of...
Research Article

Twenty-four Months Feeding on Unsaturated Dietary Fats (Virgin Olive, Sunflower, or Fish Oil) Differentially Modulate Gingival Mitochondria in the Rat

María D. Navarro-Hortal, Alfonso Varela-López, José M. Romero-Márquez, Celia Piquer-Martinez, Pedro Bullón, Tamara Y. Forbes-Hernández, José L. Quiles
Pages: 61 - 68
This study investigated the effects of feeding rats for 24 months on different unsaturated fats (virgin olive, sunflower, or fish oil) on gingival mitochondrial ultrastructure and expression of genes related to mitochondrial biology as well as the amount of circulating fatty acids in the plasma. Results...
Research Article

Random Forest, Artificial Neural Network, and Support Vector Machine Models for Honey Classification

Cecilia Martinez-Castillo, Gonzalo Astray, Juan Carlos Mejuto, Jesus Simal-Gandara
Pages: 69 - 76
Different separated protein fractions by the electrophoretic method in polyacrylamide gel were used to classify two different types of honeys, Galician honeys and commercial honeys produced and packaged outside of Galicia. Random forest, artificial neural network, and support vector machine models were...
Research Article

Phenolic Extract from Sonchus oleraceus L. Protects Diabetes-related Liver Injury in Rats through TLR4/NF-κB Signaling Pathway

Lei Chen, Xiaoyun Fan, Xiujun Lin, Liu Qian, Gokhan Zengin, Dominique Delmas, Paolo Paoli, Hui Teng, Jianbo Xiao
Pages: 77 - 84
Sonchus oleraceus Linn. is of great interest in scientific platform because it exhibits significant biological activities. This study investigated the liver protective effects and mechanism of phenolic extract from S. oleraceus (SOL) on Streptozotocin (STZ)-induced diabetic rats. SOL significantly increased...
Research Article

Effect of In vitro Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Manuka Honey

Danila Cianciosi, Tamara Yuliett Forbes-Hernández, Francesca Giampieri, Jiaojiao Zhang, Johura Ansary, Mattia Pacetti, Josè L. Quiles, Jesus Simal-Gandara, Maurizio Battino
Pages: 85 - 93
The aim of this study was to investigate and compare the change in the total content of phenolic compounds, flavonoids, and the antioxidant capacity in Manuka Honey (MH) after gastrointestinal digestion and different purification methods. MH was subjected to an in vitro gastrointestinal simulation process,...
Research Article

Comprehensive Polyphenolic Profile of Plantago depressa using High-Speed Countercurrent Chromatography Off-line with High-Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time-of-flight Tandem Mass Spectrometry

Jinju Xu, Chaoying Tong, Qiachi Fu, Keke Guo, Shuyun Shi, Yecheng Xiao
Pages: 94 - 105
The whole plant of Plantago depressa is commonly used as traditional Chinese medicine and functional food ingredient. Total phenolic content and total flavonoid content evaluation indicated that its ethyl acetate and n-butanol fractions were rich in polyphenols. However, to date, the polyphenolic profile...
Review Article

Natural Polyphenols: A Potential Therapeutic Approach to Hypoglycemia

Chao Zhao, Xuzhi Wan, Sheng Zhou, Hui Cao
Pages: 107 - 118
Natural polyphenols have been reported much attention in recent years for their hypoglycemic actions and diabetes-related pathologies. Free and simple polyphenols can be digested and absorbed in the small intestine, while complex polyphenols are utilized by intestinal flora in the large intestine. Microbial...
Review Article

Laccase-catalyzed, Phytochemical-mediated Protein Crosslinking Conjugates

Tsun-Thai Chai, Jianbo Xiao, Sharmila Mohana Dass, Fai-Chu Wong
Pages: 119 - 125
Laccase is a Class 1 oxidoreductase enzyme, which catalyzes the oxidation of a wide range of phenolic substrates. Previously, several reviews had highlighted on the industrial importance of laccase, including in food industry. Similarly, the ability of laccase to crosslink and polymerize food protein...
Review Article

Emerging Exotic Fruits: New Functional Foods in the European Market

Laura Cornara, Jianbo Xiao, Antonella Smeriglio, Domenico Trombetta, Bruno Burlando
Pages: 126 - 139
The consumption of exotic fruits is rapidly increasing in European countries. Some of these products have attracted much interest due to their alleged properties of preventing malnutrition, over-nutrition, and disease, maintaining a healthy body. Scientific studies on these fruits are multiplying, including...
Research Article

In vivo Modulatory Effect of Coffee (Coffea canephora var. Robusta) on the Expression Levels of Murine microRNA-124-3p Associated with Antioxidant Defenses

Valeria Curti, Manuela Verri, Alessandra Baldi, Marco Dacrema, Irene Masiello, Maurizia Dossena, Maria Daglia
Pages: 140 - 146
Antioxidant activity is one of the most studied properties of coffee as a beverage, and is mainly ascribed to its polyphenol content, although there is limited scientific literature regarding its mechanism of action at the molecular level. In recent years, epigenetics has been featured as a promising...
Research Article

Xanthine Oxidase Inhibitors Screening, Antioxidation, and DNA Protection Properties of Geranium wilfordii Maxim

Yi Liu, Shiyong Mei, Aiping Xiao, Liangliang Liu
Pages: 147 - 155
Geranium wilfordii Maxim is a commonly used traditional medicine and as decoction pieces in drinks for treating acute and chronic rheumatalgia. Earlier research showed it could inhibit xanthine oxidase and had a strong antioxidative activity. In this study, four compounds namely, corilagin, geraniin,...
Research Article

Trypsin-hydrolyzed Corn Silk Proteins: Antioxidant Activities, in vitro Gastrointestinal and Thermal Stability, and Hematoprotective Effects

Tsun-Thai Chai, Shin-Yii Ang, Kervine Goh, You-Han Lee, Jia-Min Ngoo, Lai-Kuan Teh, Fai-Chu Wong
Pages: 156 - 164
The aim of this study was to examine the antioxidant capacity of Trypsin-hydrolyzed corn silk proteins, specifically radical scavenging, ferric reducing and anti-lipid peroxidation activities, as well as stability after heating and simulated gastrointestinal digestion. Among the 1–5-h hydrolysates, the...
Research Article

Synthesis of CdTe Quantum Dots-based Imprinting Fluorescent Nanosensor for Highly Specific and Sensitive Determination of Caffeic Acid in Apple Juices

Ruiqing Long, Te Li, Lihui Wu, Shuyun Shi
Pages: 165 - 172
A facile method for the synthesis of molecularly imprinted polymers (MIPs) onto CdTe quantum dots (CdTe-QDs@MIPs) was successfully developed, and for the first time used as a sensitive fluorescent nanosensor for specific and rapid determination of caffeic acid (CA) in apple juices. Sol–gel polymerization...
Research Article

Data Fusion Approach Improves the Prediction of Single Phenolic Compounds in Honey: A Study of NIR and Raman Spectroscopies

Haroon Elrasheid Tahir, Muhammad Arslan, Gustav Komla Mahunu, Jiyong Shi, Xiaobo Zou, Mohammed Abdalbasit Ahmed Gasmalla, Abdalbasit Adam Mariod
Pages: 173 - 180
The combination of Near-Infrared Spectroscopy (NIR) and Raman Spectroscopy (RS) of 100 honey samples collected from different countries were used to develop the calibration model for determination of single phenolic compound. In high-performance liquid chromatography with diode-array detection analysis,...
Research Article

Response Surface Modeling for the Enrichment of Gamma-Aminobutyric Acid with a Minimum Content of Citrinin in Monascus-Fermented Rice

Washim Khan, Omkar Regmi, Mojeer Hasan, Bibhu Prasad Panda
Pages: 181 - 187
γ-Aminobutyric Acid (GABA) is a secondary metabolite produced in Monascus-fermented food. The mycotoxin (citrinin), another major secondary metabolite, is neurotoxic to humans and thus it diminishes the social acceptability of Monascus-Fermented Rice (MFR). The study was aimed to enrich GABA content...
Short Communication

Dihydromyricetin Attenuates Streptozotocin-induced Liver Injury and Inflammation in Rats via Regulation of NF-κB and AMPK Signaling Pathway

Lei Chen, Maojun Yao, Xiaoyun Fan, Xiujun Lin, Randolph Arroo, Aline Silva, Bunleu Sungthong, Simona Dragan, Paolo Paoli, Shaoyun Wang, Hui Teng, Jianbo Xiao
Pages: 188 - 195
Dihydromyricetin (DHM) dramatically improved the quality of life for Streptozotocin (STZ)-induced diabetic rats and significantly increased the activity of antioxidant enzymes in the liver. Moreover, DHM successfully ameliorated diabetes-induced liver damage by suppression of apoptosis in the liver,...
Review Article

Plant-based Food Products for Antimycobacterial Therapy

Elwira Sieniawska, Magdalena Maciejewska-Turska, Łukasz Świątek, Jianbo Xiao
Pages: 199 - 216
Traditional medicine which is based on the observations of the patient’s condition after administration of herbal remedies describes a vast number of plant species with potential application in Tuberculosis (TB) treatment. However, only a small number of plant derived secondary metabolites were shown...
Review Article

Tocotrienols in Bone Protection: Evidence from Preclinical Studies

Maureen L. Meister, Huanbiao Mo, Xiangming Ji, Chwan-Li Shen
Pages: 217 - 225
Osteoporosis is a degenerative bone disease affecting millions, mostly the aging population. Osteoblasts and osteoclasts maintain the balance in bone resorption and formation. Changes occurring in the differentiation, proliferation and activity of these two cell types result in lower bone mass and microarchitecture...
Review Article

The Anticancer Activity and Mechanisms of Ginsenosides: An Updated Review

Hongwei Chen, Haixia Yang, Daidi Fan, Jianjun Deng
Pages: 226 - 241
The annual global mortality rate of cancer has increased dramatically. Although various therapies are used for cancer, the results have not been satisfactory. Chemotherapy is currently the most common treatment option. However, serious side effects and drug resistance impede the therapeutic efficacy...
Review Article

Black Garlic: Processing, Composition Change, and Bioactivity

Hao Jing
Pages: 242 - 246
Garlic (Allium sativum L.) has been not only consumed as flavor vegetable, but also recorded as a prophylactic and therapeutic medicinal plant since ancient time. Its characteristic pungent flavor limited its application in food product development. Black garlic made from garlic by a thermal processing...
Research Article

Feed-induced Variation in the Carotenoid Composition of Brine Shrimp

Jin Huang, Bodi Hui
Pages: 247 - 253
Brine shrimp is a genus of aquatic crustacean, and is considered a dietary carotenoid resource by local residents from eastern China. In the present study, harvested brine shrimp were fed with the dried powders of tomato fruit (Solanum lycopersicum, as a lycopene source), marigold flower (Tagetes erecta...
Research Article

Antioxidant Properties and Transepithelial Transportation of Di-/tripeptides Derived from Simulated Gastrointestinal Digestion of Pig Blood Cells Hydrolysates

Xiaojun Ni, Zhenya Zhai, Zhongquan Xin, Chengquan Tan, Yiliang Chen, Jinping Deng, Pinfeng Liao, Limeng Zhang, Zaili Xiao, Baichuan Deng
Pages: 254 - 269
Pig blood is an important by-product of the meat industry, which has not been fully utilized. In this study, Pig Blood Cells (PBC) were hydrolyzed by Alcalase and followed with simulated Gastrointestinal (GI) digestion to generate bioactive peptides. The antioxidant properties and the intestinal epithelial...
Research Article

Formation of Three Selected AGEs and their Corresponding Intermediates in Aldose- and Ketose-lysine Systems

Chaoyi Xue, Zhenhua Shi, Zhiyong He, Zhaojun Wang, Fang Qin, Jie Chen, Maomao Zeng
Pages: 270 - 278
Advanced Glycation End Products (AGEs) could be formed with α-dicarbonyl compounds as intermediates; however, simultaneous determination of AGES as well as their precursors and intermediates have rarely been mentioned, so as to investigate the reaction. In this work, lysine was reacted with aldoses (galactose,...