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Volume 1, Issue 1, February 2020, Pages 2 - 11

miRNAs as Regulators of Antidiabetic Effects of Fucoidans

Authors
Chao Zhao1, Shanshan Lai1, 2, Desheng Wu1, Dan Liu1, Xiaobo Zou3, Amin Ismail4, 5, Hesham El-Seedi6, Randolph R.J. Arroo7, Jianbo Xiao8, *
1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China
3College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
4Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
5Halal Products Research Institute, Putra Infoport, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
6Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-75 123, Uppsala, Sweden
7De Montfort University, Leicester School of Pharmacy, the Gateway, Leicester LE1 9BH, UK
8Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau
*Corresponding author. Email: jianboxiao@yahoo.com
Corresponding Author
Jianbo Xiao
Received 1 July 2019, Accepted 21 August 2019, Available Online 9 September 2019.
DOI
10.2991/efood.k.190822.001How to use a DOI?
Keywords
Diabetes mellitus; miRNAs; fucoidan; antidiabetic effects; sulfated polysaccharides
Abstract

Diabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene expression toward up- or down-regulation. miRNAs have become compelling therapeutic targets and play crucial roles in regulating the process of insulin resistance. Fucoidan has shown potential function as an α-amylase inhibitor, which may be beneficial in the management of type 2 diabetes mellitus. In recent years, many studies on fucoidan focused on the decrease in blood glucose levels caused by ingesting low-glucose food or glucose-lowering components. However, the importance of miRNAs as regulators of antidiabetic effects was rarely recognized. Hence, this review emphasizes the antidiabetic mechanisms of fucoidan through regulation of miRNAs. Fucoidan exerts a vital antidiabetic effect by regulation of miRNA expression and thus provides a novel biological target for future research.

Copyright
© 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
eFood
Volume-Issue
1 - 1
Pages
2 - 11
Publication Date
2019/09/09
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.190822.001How to use a DOI?
Copyright
© 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

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TY  - JOUR
AU  - Chao Zhao
AU  - Shanshan Lai
AU  - Desheng Wu
AU  - Dan Liu
AU  - Xiaobo Zou
AU  - Amin Ismail
AU  - Hesham El-Seedi
AU  - Randolph R.J. Arroo
AU  - Jianbo Xiao
PY  - 2019
DA  - 2019/09/09
TI  - miRNAs as Regulators of Antidiabetic Effects of Fucoidans
JO  - eFood
SP  - 2
EP  - 11
VL  - 1
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.190822.001
DO  - 10.2991/efood.k.190822.001
ID  - Zhao2019
ER  -