Volume 1, Issue 1, February 2020
Review Article

2. miRNAs as Regulators of Antidiabetic Effects of Fucoidans

Chao Zhao, Shanshan Lai, Desheng Wu, Dan Liu, Xiaobo Zou, Amin Ismail, Hesham El-Seedi, Randolph R.J. Arroo, Jianbo Xiao
Pages: 2 - 11
Diabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene expression toward up- or down-regulation. miRNAs have become compelling...
Review Article

3. Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods

Wataru Aoi, Xiaobo Zou, Jian Bo Xiao, Yoshinori Marunaka
Pages: 12 - 23
Living cells have several mechanisms to avoid acidic conditions created by excess protons. The protons are extruded to the extracellular space via the plasma membrane by various types of transporters such as the Na+/H+ exchanger and monocarboxylate transporters, which hereby contribute to the exclusion...
Review Article

4. Advances in the Propolis Chemical Composition between 2013 and 2018: A Review

Luka Šturm, Nataša Poklar Ulrih
Pages: 24 - 37
Propolis is a lipophilic sticky substance collected by bees that has been used by humans for centuries. Owing to its healing, antioxidant, and other medicinal properties, its chemical composition has been widely studied. Most pharmacological properties of propolis have been attributed to its phenols...
Review Article

5. Dietary Flavonoids in the Management of Huntington’s Disease: Mechanism and Clinical Perspective

Haroon Khan, Hammad Ullah, Rosa Tundis, Tarun Belwal, Hari Prasad Devkota, Maria Daglia, Zafer Cetin, Eyup Ilker Saygili, Maria da Graça Campos, Esra Capanoglu, Ming Du, Parsa Dar, Jianbo Xiao
Pages: 38 - 52
Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive loss of neurons, which leads to behavioral systems and mental decline. HD is linked to repeat expansions of cytosine, adenine, and guanine in the Huntingtin (HTT) gene that give rise to mutation, leading to the formation...

6. Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Li-Shu Wang, Carla Elena Echeveste, Jianhua Yu, Yi-Wen Huang, John Lechner, Ling Mei, Patrick Sanvanson, Martha Yearsley, Chin-Kun Wang, Gary Stoner
Pages: 53 - 60
More than 50% of the world’s population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of...
Research Article

7. Twenty-four Months Feeding on Unsaturated Dietary Fats (Virgin Olive, Sunflower, or Fish Oil) Differentially Modulate Gingival Mitochondria in the Rat

María D. Navarro-Hortal, Alfonso Varela-López, José M. Romero-Márquez, Celia Piquer-Martinez, Pedro Bullón, Tamara Y. Forbes-Hernández, José L. Quiles
Pages: 61 - 68
This study investigated the effects of feeding rats for 24 months on different unsaturated fats (virgin olive, sunflower, or fish oil) on gingival mitochondrial ultrastructure and expression of genes related to mitochondrial biology as well as the amount of circulating fatty acids in the plasma. Results...
Research Article

8. Random Forest, Artificial Neural Network, and Support Vector Machine Models for Honey Classification

Cecilia Martinez-Castillo, Gonzalo Astray, Juan Carlos Mejuto, Jesus Simal-Gandara
Pages: 69 - 76
Different separated protein fractions by the electrophoretic method in polyacrylamide gel were used to classify two different types of honeys, Galician honeys and commercial honeys produced and packaged outside of Galicia. Random forest, artificial neural network, and support vector machine models were...
Research Article

9. Phenolic Extract from Sonchus oleraceus L. Protects Diabetes-related Liver Injury in Rats through TLR4/NF-κB Signaling Pathway

Lei Chen, Xiaoyun Fan, Xiujun Lin, Liu Qian, Gokhan Zengin, Dominique Delmas, Paolo Paoli, Hui Teng, Jianbo Xiao
Pages: 77 - 84
Sonchus oleraceus Linn. is of great interest in scientific platform because it exhibits significant biological activities. This study investigated the liver protective effects and mechanism of phenolic extract from S. oleraceus (SOL) on Streptozotocin (STZ)-induced diabetic rats. SOL significantly increased...
Research Article

10. Effect of In vitro Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds and Antioxidant Activity of Manuka Honey

Danila Cianciosi, Tamara Yuliett Forbes-Hernández, Francesca Giampieri, Jiaojiao Zhang, Johura Ansary, Mattia Pacetti, Josè L. Quiles, Jesus Simal-Gandara, Maurizio Battino
Pages: 85 - 93
The aim of this study was to investigate and compare the change in the total content of phenolic compounds, flavonoids, and the antioxidant capacity in Manuka Honey (MH) after gastrointestinal digestion and different purification methods. MH was subjected to an in vitro gastrointestinal simulation process,...
Research Article

11. Comprehensive Polyphenolic Profile of Plantago depressa using High-Speed Countercurrent Chromatography Off-line with High-Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time-of-flight Tandem Mass Spectrometry

Jinju Xu, Chaoying Tong, Qiachi Fu, Keke Guo, Shuyun Shi, Yecheng Xiao
Pages: 94 - 105
The whole plant of Plantago depressa is commonly used as traditional Chinese medicine and functional food ingredient. Total phenolic content and total flavonoid content evaluation indicated that its ethyl acetate and n-butanol fractions were rich in polyphenols. However, to date, the polyphenolic profile...