Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro
- https://doi.org/10.2991/efood.k.210222.002How to use a DOI?
- AGEs inhibition, Chinese sumac, DPP-IV inhibition, α-glucosidase inhibition, interaction
This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill. fruits on α-glucosidase, Dipeptidyl Peptidase-4 (DPP-IV), and the formation of Advanced Glycation End (AGE) products. Results showed that the TF had the strongest inhibition against α-glucosidase and DPP-IV with IC50 of 0.56 ± 0.04 and 66.08 ± 1.36 μg/mL, respectively (p < 0.05). TI exhibited the strongest inhibitory effect on the formation of AGEs with IC50 of 0.43 ± 0.03 mg/mL (p < 0.05). Two major compounds (myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside) showed additive or synergistic effects on α-glucosidase inhibition, while displayed antagonistic effect on DPP-IV inhibition. Correlation analysis indicated that myricetin-3-O-(6″-galloyl) glycoside and myricetin O-gallate contributed significantly on α-glucosidase inhibition, while di-O-galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. Protocatechuic acid and myricetin-3-O-rhamnoside showed a positive correlation with the suppression of AGEs formation. Those results may provide some scientific information for exploring R. chinensis fruits as nutraceuticals and/or functional foods to prevent or improve diabetes.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Xiaojing Liu AU - Yishan Fu AU - Qian Ma AU - Junjie Yi AU - Shengbao Cai PY - 2021 DA - 2021/03/02 TI - Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro JO - eFood SP - 37 EP - 46 VL - 2 IS - 1 SN - 2666-3066 UR - https://doi.org/10.2991/efood.k.210222.002 DO - https://doi.org/10.2991/efood.k.210222.002 ID - Liu2021 ER -