Dihydromyricetin Attenuates Streptozotocin-induced Liver Injury and Inflammation in Rats via Regulation of NF-κB and AMPK Signaling Pathway
- https://doi.org/10.2991/efood.k.200207.001How to use a DOI?
- Ampelopsin, AMPK, diabetes, dihydromyricetin, inflammation, liver-protective effects, NF-κB
Dihydromyricetin (DHM) dramatically improved the quality of life for Streptozotocin (STZ)-induced diabetic rats and significantly increased the activity of antioxidant enzymes in the liver. Moreover, DHM successfully ameliorated diabetes-induced liver damage by suppression of apoptosis in the liver, as indicated by the decreased levels of Bax and cleaved caspase-3. In diabetic rats, the levels of tumor necrosis factor-α and interleukin-1β in the liver were significantly increased. However, the administration of DHM (100–400 mg/kg/day) for 6 weeks restored the cytokine levels to their normal values in a dose-dependent manner in diabetic rats by the regulation of nuclear factor-kappa B signaling pathway. In addition, DHM significantly induced 5′ AMP-activated protein kinase (AMPK) phosphorylation and decreased MyD88, TLR4, p38, GSK-3β protein expression levels in the liver of diabetic rats. In conclusion, DHM could improve STZ-induced liver impairment by preventing oxidative stress, apoptosis, and inflammation.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Lei Chen AU - Maojun Yao AU - Xiaoyun Fan AU - Xiujun Lin AU - Randolph Arroo AU - Aline Silva AU - Bunleu Sungthong AU - Simona Dragan AU - Paolo Paoli AU - Shaoyun Wang AU - Hui Teng AU - Jianbo Xiao PY - 2020 DA - 2020/02 TI - Dihydromyricetin Attenuates Streptozotocin-induced Liver Injury and Inflammation in Rats via Regulation of NF-κB and AMPK Signaling Pathway JO - eFood SP - 188 EP - 195 VL - 1 IS - 2 SN - 2666-3066 UR - https://doi.org/10.2991/efood.k.200207.001 DO - https://doi.org/10.2991/efood.k.200207.001 ID - Chen2020 ER -