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Volume 1, Issue 2, April 2020, Pages 188 - 195

Dihydromyricetin Attenuates Streptozotocin-induced Liver Injury and Inflammation in Rats via Regulation of NF-κB and AMPK Signaling Pathway

Authors
Lei Chen1, Maojun Yao2, Xiaoyun Fan1, Xiujun Lin1, Randolph Arroo3, Aline Silva4, Bunleu Sungthong5, Simona Dragan6, Paolo Paoli7, Shaoyun Wang8, Hui Teng1, *, Jianbo Xiao9, *
1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China
2College of Chemistry and Chemical Engineering, Jishou University, Jishou, China
3Leicester School of Pharmacy, De Montfort University, Leicester, UK
4Department of Horticulture, Michigan State University, East Lansing, MI, USA
5Faculty of Pharmacy, Mahasarakham University, Kham Riang, Kantharawichai, Maha Sarakham, Thailand
6Department of Cardiology, Faculty of Medicine, University of Medicine and Pharmacy “Victor Babeș”, Timișoara, Romania
7Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
8College of Biological Science and Technology, Fuzhou University, Fuzhou, China
9Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China
*Corresponding authors. Email: tenghui850610@126.com; jianboxiao@yahoo.com
Corresponding Authors
Hui Teng, Jianbo Xiao
Received 1 August 2019, Accepted 28 January 2020, Available Online 19 February 2020.
DOI
10.2991/efood.k.200207.001How to use a DOI?
Keywords
Ampelopsin; AMPK; diabetes; dihydromyricetin; inflammation; liver-protective effects; NF-κB
Abstract

Dihydromyricetin (DHM) dramatically improved the quality of life for Streptozotocin (STZ)-induced diabetic rats and significantly increased the activity of antioxidant enzymes in the liver. Moreover, DHM successfully ameliorated diabetes-induced liver damage by suppression of apoptosis in the liver, as indicated by the decreased levels of Bax and cleaved caspase-3. In diabetic rats, the levels of tumor necrosis factor-α and interleukin-1β in the liver were significantly increased. However, the administration of DHM (100–400 mg/kg/day) for 6 weeks restored the cytokine levels to their normal values in a dose-dependent manner in diabetic rats by the regulation of nuclear factor-kappa B signaling pathway. In addition, DHM significantly induced 5′ AMP-activated protein kinase (AMPK) phosphorylation and decreased MyD88, TLR4, p38, GSK-3β protein expression levels in the liver of diabetic rats. In conclusion, DHM could improve STZ-induced liver impairment by preventing oxidative stress, apoptosis, and inflammation.

Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
eFood
Volume-Issue
1 - 2
Pages
188 - 195
Publication Date
2020/02/19
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.200207.001How to use a DOI?
Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Lei Chen
AU  - Maojun Yao
AU  - Xiaoyun Fan
AU  - Xiujun Lin
AU  - Randolph Arroo
AU  - Aline Silva
AU  - Bunleu Sungthong
AU  - Simona Dragan
AU  - Paolo Paoli
AU  - Shaoyun Wang
AU  - Hui Teng
AU  - Jianbo Xiao
PY  - 2020
DA  - 2020/02/19
TI  - Dihydromyricetin Attenuates Streptozotocin-induced Liver Injury and Inflammation in Rats via Regulation of NF-κB and AMPK Signaling Pathway
JO  - eFood
SP  - 188
EP  - 195
VL  - 1
IS  - 2
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200207.001
DO  - 10.2991/efood.k.200207.001
ID  - Chen2020
ER  -