eFood

Volume 2, Issue 2, April 2021, Pages 81 - 91

Evaluation of Acute and Subacute Toxicity of Two Different Extracts from Que Zui Tea in Rats

Authors
Yongpeng Wang1, , Guy Sedar Singor Njateng1, 2, , Tianrui Zhao1, Meilian Yang1, Yifen Wang3, Jianxin Cao1, Yaping Liu1, Guiguang Cheng1, *
1Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming 650500, China
2Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon
3Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

These authors have contributed equally to this work.

*Corresponding author. Email: ggcheng@kust.edu.cn
Corresponding Author
Guiguang Cheng
Received 1 February 2021, Accepted 27 March 2021, Available Online 3 April 2021.
DOI
https://doi.org/10.2991/efood.k.210329.002How to use a DOI?
Keywords
Que Zui tea, acute-toxicity, subacute-toxicity, hematology, biochemistry, histopathology
Abstract

The buds of Vaccinium dunalianum Wight (VD) are widely used in Yunnan as herbal tea [Que Zui Tea (QT)] and herb. However, the security and toxicity of QT have not been determined yet. The aim of this study is to evaluate the acute and subacute-toxicity of hot water (QTW) and aqueous-ethanol (QTE) extracts of QT. Acute-toxicity studies of QTW and QTE revealed no signs of related to treatment, indicating that median-lethal-dose (LD50) values of QTW and QTE is surpass 5000 mg/kg. The results of subacute-toxicity studies of QTW and QTE showed no significant side reaction of all doses the two extracts. The levels of Lymphocyte (LYM) and percentage of lymphocytes (LYM%) significantly decreased, and percentage of granulocytes (GRA%) increased in rats that received these two extracts at doses greater than 1250 mg/kg/day. However, the 1250 and 2500 mg/kg/day QTW and QTE did not trigger any pathological changes in body weight or organ tissue, so partial changes in blood parameters were considered as minor symptoms. Therefore, the present results demonstrated that the two extracts are safe at 2500 mg/kg/day or at lower doses.

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Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
eFood
Volume-Issue
2 - 2
Pages
81 - 91
Publication Date
2021/04/03
ISSN (Online)
2666-3066
DOI
https://doi.org/10.2991/efood.k.210329.002How to use a DOI?
Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Yongpeng Wang
AU  - Guy Sedar Singor Njateng
AU  - Tianrui Zhao
AU  - Meilian Yang
AU  - Yifen Wang
AU  - Jianxin Cao
AU  - Yaping Liu
AU  - Guiguang Cheng
PY  - 2021
DA  - 2021/04/03
TI  - Evaluation of Acute and Subacute Toxicity of Two Different Extracts from Que Zui Tea in Rats
JO  - eFood
SP  - 81
EP  - 91
VL  - 2
IS  - 2
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.210329.002
DO  - https://doi.org/10.2991/efood.k.210329.002
ID  - Wang2021
ER  -