eFood

Volume 2, Issue 2, April 2021, Pages 59 - 72

Behavior of Non-Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti-Obesity Effect

Authors
Yajun Zhang1, Qingtong Xie1, Lijun You1, 2, *, Peter Chi-Keung Cheung3, Zhengang Zhao1
1School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510640, China
2Overseas Expertise Introduction Center for Food Nutrition and Human Health (111 Center), Guangzhou, Guangdong 510640, China
3Food and Nutritional Sciences, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
*Corresponding author. Email: feyoulijun@scut.edu.cn
Corresponding Author
Lijun You
Received 18 January 2021, Accepted 10 March 2021, Available Online 18 March 2021.
DOI
https://doi.org/10.2991/efood.k.210310.001How to use a DOI?
Keywords
Gastrointestinal tract, obesity, microbiota, non-digestible polysaccharides, digestion, fermentation
Abstract

Nowadays, obesity in humans is a huge challenge requiring effective, readily available, and low-risk alternative treatments. Intake of edible Non-Digestible Polysaccharides (NDPs) is regarded as a promising strategy to combat obesity. Herein, an overview of the behavior of NDPs in the Gastrointestinal (GI) tract and its association with anti-obesity effect is summarized. Both the in vitro and in vivo of such investigations are discussed. Results show that NDPs can reach the large intestine to mediate the gut microbiota with the extent of regulation varies among NDPs with different chemical structures. The possible anti-obesity mechanisms associated with behavior of NDPs in the GI tract include: (i) inhibition of fat absorption, (ii) modification of gut microbiota and their metabolites such as short-chain fatty acids, (iii) regulation of bile acid profiles, (iv) modulation on appetite and satiety effect, and (v) protection of intestinal barrier. However, more efforts are required to clarify the exact behavior and their beneficial effects of NDPs within GI tract. This paper will provide an overlook of recent advances for better understanding anti-obesity activity of NDPs.

HIGHLIGHTS
  • An overview of in vitro and in vivo studies on the behavior of edible Non-Digestible Polysaccharides (NDPs) in the Gastrointestinal (GI) tract is presented.

  • The anti-obesity mechanisms of NDPs based on their GI behavior are discussed.

Graphical Abstract

Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

Journal
eFood
Volume-Issue
2 - 2
Pages
59 - 72
Publication Date
2021/03/18
ISSN (Online)
2666-3066
DOI
https://doi.org/10.2991/efood.k.210310.001How to use a DOI?
Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Yajun Zhang
AU  - Qingtong Xie
AU  - Lijun You
AU  - Peter Chi-Keung Cheung
AU  - Zhengang Zhao
PY  - 2021
DA  - 2021/03/18
TI  - Behavior of Non-Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti-Obesity Effect
JO  - eFood
SP  - 59
EP  - 72
VL  - 2
IS  - 2
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.210310.001
DO  - https://doi.org/10.2991/efood.k.210310.001
ID  - Zhang2021
ER  -