Behavior of Non-Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti-Obesity Effect
- https://doi.org/10.2991/efood.k.210310.001How to use a DOI?
- Gastrointestinal tract; obesity; microbiota; non-digestible polysaccharides; digestion; fermentation
Nowadays, obesity in humans is a huge challenge requiring effective, readily available, and low-risk alternative treatments. Intake of edible Non-Digestible Polysaccharides (NDPs) is regarded as a promising strategy to combat obesity. Herein, an overview of the behavior of NDPs in the Gastrointestinal (GI) tract and its association with anti-obesity effect is summarized. Both the in vitro and in vivo of such investigations are discussed. Results show that NDPs can reach the large intestine to mediate the gut microbiota with the extent of regulation varies among NDPs with different chemical structures. The possible anti-obesity mechanisms associated with behavior of NDPs in the GI tract include: (i) inhibition of fat absorption, (ii) modification of gut microbiota and their metabolites such as short-chain fatty acids, (iii) regulation of bile acid profiles, (iv) modulation on appetite and satiety effect, and (v) protection of intestinal barrier. However, more efforts are required to clarify the exact behavior and their beneficial effects of NDPs within GI tract. This paper will provide an overlook of recent advances for better understanding anti-obesity activity of NDPs.
An overview of in vitro and in vivo studies on the behavior of edible Non-Digestible Polysaccharides (NDPs) in the Gastrointestinal (GI) tract is presented.
The anti-obesity mechanisms of NDPs based on their GI behavior are discussed.
- Graphical Abstract
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- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Yajun Zhang AU - Qingtong Xie AU - Lijun You AU - Peter Chi-Keung Cheung AU - Zhengang Zhao PY - 2021 DA - 2021/03/18 TI - Behavior of Non-Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti-Obesity Effect JO - eFood SP - 59 EP - 72 VL - 2 IS - 2 SN - 2666-3066 UR - https://doi.org/10.2991/efood.k.210310.001 DO - https://doi.org/10.2991/efood.k.210310.001 ID - Zhang2021 ER -