Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon

Souha S. Kanj; Zeina A. Kanafani; Marwa Shehab; Nisreen Sidani; Tania Baban; Kedak Baltajian; Ghenwa K. Dakdouki; Mohamad Zaatari; George F. Araj; Rima Hanna Wakim; Ghassan Dbaibo; Ghassan M. Matar

doi:10.1016/j.jegh.2014.07.003

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Volume 5, Issue 2, June 2015, Pages 159 - 165

Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon

Authors

Souha S. Kanj^a^{, b}^{, *}^,sk11@aub.edu.lb, Zeina A. Kanafani^a^{, b}, Marwa Shehab^b^{, c}^{, 1}, Nisreen Sidani^a^{, 1}, Tania Baban^a^{, b}, Kedak Baltajian^a, Ghenwa K. Dakdouki^d, Mohamad Zaatari^d, George F. Araj^b^{, e}, Rima Hanna Wakim^b^{, f}, Ghassan Dbaibo^b^{, f}, Ghassan M. Matar^b^{, c}

^aDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

^bCenter for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon

^cDepartment of Experimental Pathology, Microbiology and Immunology, American University of Beirut Medical Center, Beirut, Lebanon

^dHammoud Hospital University Medical Center, Sidon, Lebanon

^eDepartment of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon

^fDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

¹

Both authors contributed equally to the manuscript.

^*Corresponding author at: Department of Internal Medicine, Division of Infectious Diseases, American University of Beirut Medical Center, PO Box 11-0236 Cairo Street, Riad El Solh 1107 2020, Beirut, Lebanon. Tel.: +961 1350000x5381; fax: +961 1 370814.

Corresponding Author

Souha S. Kanjsk11@aub.edu.lb

Received 5 November 2013, Revised 13 July 2014, Accepted 17 July 2014, Available Online 10 September 2014.

DOI: 10.1016/j.jegh.2014.07.003 How to use a DOI?
Keywords: Salmonella typhi; Typhoid fever; Enteric fever; Food borne diseases; Molecular typing; Middle east
Abstract: The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified from various areas of the country based on positive culture results for S. typhi from blood, urine, stools, bone marrow and/or positive serology. Clinical, microbiological and molecular analysis was performed on cases with complete data available. These results indicated that drinking water was an unlikely mode of transmission of the infection. Despite increasing reports of antimicrobial resistance among S. typhi isolates, the vast majority of these isolates were susceptible to various antibiotic agents, including ampicillin, cephalosporins, quinolones, and trimethoprim/sulfamethoxazole. Molecular analysis of the isolates revealed a predominance of one single genotype with no variation in distribution across the geographical regions.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 5 - 2
Pages: 159 - 165
Publication Date: 2014/09/10
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2014.07.003 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Souha S. Kanj
AU  - Zeina A. Kanafani
AU  - Marwa Shehab
AU  - Nisreen Sidani
AU  - Tania Baban
AU  - Kedak Baltajian
AU  - Ghenwa K. Dakdouki
AU  - Mohamad Zaatari
AU  - George F. Araj
AU  - Rima Hanna Wakim
AU  - Ghassan Dbaibo
AU  - Ghassan M. Matar
PY  - 2014
DA  - 2014/09/10
TI  - Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon
JO  - Journal of Epidemiology and Global Health
SP  - 159
EP  - 165
VL  - 5
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2014.07.003
DO  - 10.1016/j.jegh.2014.07.003
ID  - Kanj2014
ER  -

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