Synthesis of 2-(4-((6-bromo-3-nitroquinolin-4-yl)amino) phenyl)-2-methylpropanenitrile
Fei Lei, Yuanbiao Tu, Min Wang, WenHui Wang, Qidong Tang, Shan Xu
Available Online May 2015.
- 10.2991/asei-15.2015.423How to use a DOI?
- PI3K/mTOR inhibitors,6-bromoquinolin-4-ol,Synthesis
2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitril(7) is an important intermediate in many PI3K/mTOR inhibitors. The compound 5 was synthesized from 6-bromoquinolin-4-ol (1) and 2-(4-nitrophenyl)acetonitrile(4) through five steps including nitration, chlorination, alkylation, reduction and substitution. These structures were confirmed by 1HNMR and MS spectrum. The synthetic method of 7 was optimized and can be used to synthesize the derivatives of NVP-BEZ235.
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Fei Lei AU - Yuanbiao Tu AU - Min Wang AU - WenHui Wang AU - Qidong Tang AU - Shan Xu PY - 2015/05 DA - 2015/05 TI - Synthesis of 2-(4-((6-bromo-3-nitroquinolin-4-yl)amino) phenyl)-2-methylpropanenitrile BT - Proceedings of the 2015 International conference on Applied Science and Engineering Innovation PB - Atlantis Press SP - 2154 EP - 2157 SN - 2352-5401 UR - https://doi.org/10.2991/asei-15.2015.423 DO - 10.2991/asei-15.2015.423 ID - Lei2015/05 ER -