Transcriptome Reveals That Genic SNPs Contributes to Heterosis in Cattle

DOI

10.2991/bst-17.2018.17How to use a DOI?

Keywords

Allele-specific gene expression, Coat color, Cattle, Transcriptome.

Abstract

Heterosis is a powerful and valuable tool for commercial beef producers, especially cow calf operations. Despite the importance of heterosis, and its extensive genetic analysis, little understanding exists of its molecular basis. We applied RNA-Seq technology to assess transcriptome-wide allele-specific gene expression (ASGE) in the hybrid genetic background at economic traits of offspring and maternal. 120 genes of these were different expression among three individuals in common. Among these genes, we found that three genes involved in melanogenesis pathway, including MC1R, DCT and TYR. In addition six of the altered expression genes were related to arachidonic acid (AA) metabolism, such as PTGS1, PTGIS, PTGR1, ALOX12B, ALOX15B and EPHX2. We find that coat color traits could be utilized to check the analysis pipeline for heterosis studies. Results from this study indicate that the parental alleles have un-equivalent functions in the hybrid, which may have an impact on heterosis.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jiang-Hong Wu
AU  - Husile Gong
AU  - Qing-Jiang Luan
AU  - Ling Xue
AU  - Hai-Lian Sun
AU  - Feng Wang
PY  - 2018/02
DA  - 2018/02
TI  - Transcriptome Reveals That Genic SNPs Contributes to Heterosis in Cattle
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 110
EP  - 121
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.17
DO  - 10.2991/bst-17.2018.17
ID  - Wu2018/02
ER  -