Upgrading Indonesian Local Ethnomedicinal Knowledge with Molecular Phylogenetics

DOI

10.2991/aer.k.200325.059How to use a DOI?

Keywords

Indonesia, ethnomedicine, molecular phylogenetics, Global Biodiversity Information Facility, DNA barcoding

Abstract

With at least 200 ethnic groups and 30.000 medicinal plants used in Jamu formulations, Indonesia is one of the largest natural drug dispensaries in the world. Ethnomedicine-directed bioprospecting has been used to accelerate drug discovery. Little is known about the coverage of ethnomedicinal studies in Indonesia. The quest to obtain drugs from plants also remains elusive. Nature-derived approved drugs worldwide have come mostly from drug-productive families that tend to be clustered in the phylogenetic tree, thus these families should be the basis of bioprospecting focus. We presented a review of ethnomedicinal research conducted across Indonesia and recommend strategic approaches to accelerate the translation of traditional knowledge into the clinic. We identified several plant species commonly used with similar or different purposes within different places, empirical pharmacological studies, regions that are understudied, and comparison with plants whose metabolites have been used for the development of approved medicine worldwide. Combination of ethnomedicinal knowledge with molecular phylogenetics, -omics, Bioactivity-guided bioprospecting, DNA barcoding, and Global Biodiversity Information Facility (GBIF) software will enable more efficient and environmentally friendly drug discovery process as well as commercial production. Altogether, this proposed method will be a game-changer in the exploration of the largely untapped chemical diversity of Indonesian flora.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - AC Brazia
AU  - LT Adi
AU  - MR Kaho
AU  - Lindawati
AU  - Rosaria
AU  - H Rustiami
AU  - E Sukara
PY  - 2020
DA  - 2020/03/30
TI  - Upgrading Indonesian Local Ethnomedicinal Knowledge with Molecular Phylogenetics
BT  - Proceedings of the 5th International Conference on Food, Agriculture and Natural Resources (FANRes 2019)
PB  - Atlantis Press
SP  - 297
EP  - 305
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.200325.059
DO  - 10.2991/aer.k.200325.059
ID  - Brazia2020
ER  -