Evaluation of the sedative and hypnotic effects of ethanol-extract isolated from Herba Agrimoniae in mice

DOI

10.2991/icaset-18.2018.43How to use a DOI?

Keywords

Insomnia, Herba Agrimoniae, Sedative??"hypnotic effects, Pentobarbital sleep

Abstract

The purpose of this study was to evaluate the sedative and hypnotic activities of ethanol-extract isolated from Herba Agrimoniae on the central nervous system. Herba Agrimoniae has been used as a traditional herbal medicine for treating various cancers and diseases in traditional Chinese medicine. In the experiments, the extract of Herba Agrimoniae showed signifcant effects on mice, including reduced spontaneous activity, increased sleep ratio, shortened sleep latency and lengthened sleep time with a subthreshold or superthreshold dose of pentobarbital sodium. These findings confirmed that ethanol-extract isolated from Herba Agrimoniae had sedative and hypnotic effects and has potential to be preferable for the treatment of insomnia.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Chang-lei Li
AU  - Zhong-ze Lou
AU  - Xiao-qing Chen
AU  - Hui-ling Yi
AU  - Meng-jia Chen
AU  - Bao-miao Ma
PY  - 2018/04
DA  - 2018/04
TI  - Evaluation of the sedative and hypnotic effects of ethanol-extract isolated from Herba Agrimoniae in mice
BT  - Proceedings of the 2018 8th International Conference on Applied Science, Engineering and Technology (ICASET 2018)
PB  - Atlantis Press
SP  - 214
EP  - 218
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaset-18.2018.43
DO  - 10.2991/icaset-18.2018.43
ID  - Li2018/04
ER  -