Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System
Authors
Yingzong Ren, Xue-Jie Qi, Yuanlu Cui
Corresponding Author
Yingzong Ren
Available Online July 2015.
- DOI
- 10.2991/icimm-15.2015.129How to use a DOI?
- Keywords
- Themosensitive hydrogel; Orthogonal Design; Guanidine-Chitosan; Poloxamer
- Abstract
A novel themosensitive in situ gel was prepared by using Poloxamer407 and poloxamer188 combined with membrane penetration enhancer Guanidine-Chitosan. Orthogonal experiment optimization was used to study of formulations conditions that suit to intranasal drug delivery. The optimal intranasal gel formulation has been further checked for viscosity behavior against temperature. The result showed that the optimal formulation was 18% P407 (w/w), 3% P188 (w/w), 2% GCS (w/w), which have prospective gelation temperature 29.5 °C. Evaluation of Guanidine-chitosan influence in gelation temperature showed slight decrease the point of hydrogel system.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yingzong Ren AU - Xue-Jie Qi AU - Yuanlu Cui PY - 2015/07 DA - 2015/07 TI - Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System BT - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials PB - Atlantis Press SP - 686 EP - 689 SN - 2352-5401 UR - https://doi.org/10.2991/icimm-15.2015.129 DO - 10.2991/icimm-15.2015.129 ID - Ren2015/07 ER -