An Overview of Existing Animal Models of Post-traumatic Stress Disorder Regarding Validity and Ethics

DOI

10.2991/assehr.k.220110.184How to use a DOI?

Keywords

Animal models; PTSD; Electric shock; Underwater trauma; Social defeat; Direct predator exposure; Predator odor exposure

Abstract

Animal models have historically played a significant role in the overall understanding of the underlying pathology of human diseases, as well as development and validation of novel therapeutic treatments. In the past few decades, they have been heavily used in researches regarding post-traumatic stress disorder (PTSD). While the animal models have remarkably contributed to the field at both genetic and molecular levels, there has been rising conversation questioning the efficacy of commonly used animal models in terms of investigating PTSD, which is known to be a relatively complex disorder. This review analyzes various types of currently existing animal models with different stressors being used. The analysis of this review is based on the criteria of evaluation proposed by Yehuda and Antelman in 1993, as well as the ethical standards of conducting animal studies. While examining the trade-off between the validity of animal models and animal welfare, this review is intended to make a proper evaluation of advantages and limitations of existing animal models and provide innovative insights and possible improvements in the future. As for the animal models mentioned in this review, no single one has attained high validity and ethical standards at the same time, which means there is still progress to be made in future animal studies for PTSD.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yijie Lian
PY  - 2022
DA  - 2022/01/28
TI  - An Overview of Existing Animal Models of Post-traumatic Stress Disorder Regarding Validity and Ethics
BT  - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021)
PB  - Atlantis Press
SP  - 975
EP  - 979
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220110.184
DO  - 10.2991/assehr.k.220110.184
ID  - Lian2022
ER  -