Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

Congenital Missing Teeth

Authors
Jessica Anggono, Elza Ibrahim Auerkari
Corresponding Author
Jessica Anggono
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.12How to use a DOI?
Keywords
Congenital missing teeth, Genetics, Gene mutations
Abstract
Oral health plays a major role in an individual’s well-being, affecting all aspects of quality of life: esthetics, function, and speech. Abnormalities in oral health may disrupt any or all of these aspects. One of the challenging and most common dental anomalies found in daily practice is congenital missing teeth (CMT). CMT affects more than 20% of the human population and can negatively affect mouth esthetics, dental function, and even a person’s speech. CMT essentially re-sult from a defect in tooth development, which is a complex process. Environ-mental and genetic factors, combined with epigenetics, have been credited with disrupting tooth development, causing CMT. Most cases of CMT are found in a familial pattern, and among all factors, genetics plays a fundamental part; there-fore, heredity has a crucial role in determining an individual’s phenotype of CMT. There are more than 300 genes that contribute to odontogenesis, and their muta-tions may be manifest as hypodontia with varying degrees of penetrance and ex-pressivity. A major cause of autosomal dominant non-syndromic hypodontia is mutation in the MSX1 and PAX9 genes in humans. In the present paper, we will discuss in brief the definition, prevalence, etiology, and roles of genetics and epi-genetics in CMT, as well as the types of gene mutation, with emphasis on muta-tion in the MSX1 and PAX9 genes related to CMT.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.12How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Jessica Anggono
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - Congenital Missing Teeth
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.12
DO  - https://doi.org/10.2991/idsm-17.2018.12
ID  - Anggono2018/05
ER  -