Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

Genetic and Epigenetic Aspects of Crouzon’s Syndrome

Authors
Nasytha Vikarina Siregar, Elza Ibrahim Auerkari
Corresponding Author
Nasytha Vikarina Siregar
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.23How to use a DOI?
Keywords
crouzon’s syndrome, craniosynostosis, mutation, FGFR2 gene
Abstract
Crouzon’s syndrome is a genetic disorder characterized by a distinctive malfor-mation of the skull and facial region resulting from the premature fusion of the cranial sutures, abnormal growth of bones, and facial deformities caused by the underdevelopment of the midfacial region and hypertelorism. This syndrome is rare, with a prevalence of 16 cases among every million births worldwide. Muta-tions in the gene encoding fibroblast growth factor receptor 2 (FGFR2) have been identified as the main causative factors of autosomal dominant Crouzon’s syn-drome. However, Crouzon’s syndrome may emerge as the result of a de novo mutation, in addition to its transmission as an autosomal dominant genetic condi-tion. Crouzon’s syndrome may also result from epigenetic mechanisms, such as a decrease in microRNA-338 expression that promotes increases FGFR2 expression and, consequently, enhanced osteoblast differentiation. This work aims to briefly review Crouzon’s syndrome in the context of its genetic and epigenetic aspects, with the aim of allowing clinicians to more readily predict a patient’s orthopedic condition before initiating orthodontic treatment.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)

Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.23How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Nasytha Vikarina Siregar
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - Genetic and Epigenetic Aspects of Crouzon’s Syndrome
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.23
DO  - https://doi.org/10.2991/idsm-17.2018.23
ID  - Siregar2018/05
ER  -