Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)

Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis

Authors
Dahlia Herawati
Corresponding Author
Dahlia Herawati
Available Online May 2018.
DOI
https://doi.org/10.2991/idsm-17.2018.38How to use a DOI?
Keywords
aggressive periodontitis, vitamin D and dexamethasone, osteoblasts, estrogen re-ceptor α, androgen receptor
Abstract
The objective of this study is to investigate the expression of estrogen receptor α and androgen receptor in osteoblasts derived from patients with aggressive perio-dontitis following stimulation using vitamin D and dexamethasone. Sample pieces of alveolar bone were collected from patients with aggressive periodontitis (PA) and from non-periodontitis subjects (NP), for both of which the patient's consent had been obtained. Osteoblasts were isolated from bone fragments by the explant method, stimulated with vitamin D and dexamethasone, and then examined for the expression of ERα and AR using immunohistochemical staining. Increased expression of ERα-PA (RR: 1.1; CC: 0.61 to 1.99; p = 752) and ARC-PA (RR: 1.62; CI: 0.87-3, p = 0.13) determined that vitamin D and dexamethasone stimu-lated osteoblasts showed increased receptor expression than those from healthy controls (non-periodontitis). Stimulation using vitamin D and dexamethasone in-creased the expression of ERα, and AR in the osteoblasts.
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Proceedings
11th International Dentistry Scientific Meeting (IDSM 2017)
Part of series
Advances in Health Sciences Research
Publication Date
May 2018
ISBN
978-94-6252-513-9
ISSN
2468-5739
DOI
https://doi.org/10.2991/idsm-17.2018.38How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Dahlia Herawati
PY  - 2018/05
DA  - 2018/05
TI  - Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis
BT  - 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.38
DO  - https://doi.org/10.2991/idsm-17.2018.38
ID  - Herawati2018/05
ER  -