Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis
- Dahlia Herawati
- Corresponding Author
- Dahlia Herawati
Available Online May 2018.
- https://doi.org/10.2991/idsm-17.2018.38How to use a DOI?
- aggressive periodontitis, vitamin D and dexamethasone, osteoblasts, estrogen re-ceptor α, androgen receptor
- The objective of this study is to investigate the expression of estrogen receptor α and androgen receptor in osteoblasts derived from patients with aggressive perio-dontitis following stimulation using vitamin D and dexamethasone. Sample pieces of alveolar bone were collected from patients with aggressive periodontitis (PA) and from non-periodontitis subjects (NP), for both of which the patient's consent had been obtained. Osteoblasts were isolated from bone fragments by the explant method, stimulated with vitamin D and dexamethasone, and then examined for the expression of ERα and AR using immunohistochemical staining. Increased expression of ERα-PA (RR: 1.1; CC: 0.61 to 1.99; p = 752) and ARC-PA (RR: 1.62; CI: 0.87-3, p = 0.13) determined that vitamin D and dexamethasone stimu-lated osteoblasts showed increased receptor expression than those from healthy controls (non-periodontitis). Stimulation using vitamin D and dexamethasone in-creased the expression of ERα, and AR in the osteoblasts.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Dahlia Herawati PY - 2018/05 DA - 2018/05 TI - Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis BT - 11th International Dentistry Scientific Meeting (IDSM 2017) PB - Atlantis Press SN - 2468-5739 UR - https://doi.org/10.2991/idsm-17.2018.38 DO - https://doi.org/10.2991/idsm-17.2018.38 ID - Herawati2018/05 ER -