Benzothiazole Derivative Accelerates Excretion of Total Sterols in Long-Term High Fat Fed C57BL/6J Mice
- Y. Yu, H. Jiang, J.L. Ao, H. Wang, E.B. Hua
- Corresponding Author
- Y. Yu
Available Online March 2016.
- https://doi.org/10.2991/meep-15.2016.46How to use a DOI?
- excretion; total sterols; mRNA regulation; benzothiazole derivative
- Benzothiazole derivative (BD): [N-(3-(benzothiazol- 2-yl) phenyl)-1H-pyrazole-3-carboxamide] was tested for excretion of total sterols of high-fat diet fed C57BL/6J mice in view of lipid metabolism. The results showed that BD as supplementation of high-fat diet significantly improved the output of cholesterol in comparison to HF alone. Relevant mRNA expressions of HMG-CoA-R, SREBP-2, LDL-R, CYP7A1 and PPAR were significantly altered in liver. These results suggest that BD could promote the excretion of total sterols and play a beneficial role in lipids metabolism for a high-fat fed mice.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Y. Yu AU - H. Jiang AU - J.L. Ao AU - H. Wang AU - E.B. Hua PY - 2016/03 DA - 2016/03 TI - Benzothiazole Derivative Accelerates Excretion of Total Sterols in Long-Term High Fat Fed C57BL/6J Mice BT - International Conference on Materials Chemistry and Environmental Protection 2015 PB - Atlantis Press SN - 2352-541X UR - https://doi.org/10.2991/meep-15.2016.46 DO - https://doi.org/10.2991/meep-15.2016.46 ID - Yu2016/03 ER -