Benzothiazole Derivative Accelerates Excretion of Total Sterols in Long-Term High Fat Fed C57BL/6J Mice

DOI

10.2991/meep-15.2016.46How to use a DOI?

Keywords

excretion; total sterols; mRNA regulation; benzothiazole derivative

Abstract

Benzothiazole derivative (BD): [N-(3-(benzothiazol- 2-yl) phenyl)-1H-pyrazole-3-carboxamide] was tested for excretion of total sterols of high-fat diet fed C57BL/6J mice in view of lipid metabolism. The results showed that BD as supplementation of high-fat diet significantly improved the output of cholesterol in comparison to HF alone. Relevant mRNA expressions of HMG-CoA-R, SREBP-2, LDL-R, CYP7A1 and PPAR were significantly altered in liver. These results suggest that BD could promote the excretion of total sterols and play a beneficial role in lipids metabolism for a high-fat fed mice.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Y. Yu
AU  - H. Jiang
AU  - J.L. Ao
AU  - H. Wang
AU  - E.B. Hua
PY  - 2016/03
DA  - 2016/03
TI  - Benzothiazole Derivative Accelerates Excretion of Total Sterols in Long-Term High Fat Fed C57BL/6J Mice
BT  - Proceedings of the 2015 International Conference on Materials Chemistry and Environmental Protection (meep-15)
PB  - Atlantis Press
SP  - 174
EP  - 177
SN  - 2352-541X
UR  - https://doi.org/10.2991/meep-15.2016.46
DO  - 10.2991/meep-15.2016.46
ID  - Yu2016/03
ER  -