Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model
- DOI
- 10.2991/ssemse-15.2015.326How to use a DOI?
- Keywords
- Total anthraquinone of Polygonum cuspidatum (TAPC); Diabete model; Streptozotocin; Insulin antibody; Leptin; C-peptide.
- Abstract
To investigate the effect of total anthraquinone of Polygonum cuspidatum (TAPC) in diabete rats which were established by streptozotocin. Method: The diabete rat model was established by injected with streptozotocin, and then randomized into 5 groups. Which were fed with high dosage TAPC group, medium dosage TAPC group, low dosage TAPC group (400mg•kg-1,200mg•kg-1,100mg•kg-1), metformin group (208 mg•kg 1) and model group. Control group was set up with healthy normal rats. All the rats were administrated once a day for 30 days. Blood glucose (BG) in the limosis were measured on the 20, 30 day and then rats were sacrificed. The levels of insulin, insulin antibody, leptin, C-peptide in orbital blood were measured. Results: Diabetic model rats successfully. Compared with model group, The high dosage TAPC group can significantly reduce the level of blood suga on 30 day(P<0.01), Can significantly reduce the level of blood suga on 20 day (P<0.05); The medium dosage TAPC group significantly reduce the level of blood suga on 20, 30 day (P<0.01); The medium and low dosage TAPC group significantly increased the level of insulin (P<0.01); Each dosage TAPC group can significantly reduce the level of C-peptide (P<0.01). Conclusion: TAPC has good hypoglycemic effect on the diabete rats established by injection of streptozotocin
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ming Bai AU - Yan Li AU - Mingsan Miao AU - Ting Wang AU - Yuyin Xu PY - 2015/11 DA - 2015/11 TI - Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model BT - Proceedings of the 2015 International Conference on Social Science, Education Management and Sports Education PB - Atlantis Press SP - 1267 EP - 1270 SN - 2352-5398 UR - https://doi.org/10.2991/ssemse-15.2015.326 DO - 10.2991/ssemse-15.2015.326 ID - Bai2015/11 ER -