Journal of Epidemiology and Global Health

<Previous Article In Issue
Next Article In Issue>
Volume 7, Issue 2, June 2017, Pages 111 - 118

Magnitude and determinants of adverse treatment outcomes among tuberculosis patients registered under Revised National Tuberculosis Control Program in a Tuberculosis Unit, Wardha, Central India: A record-based cohort study

Authors
Anuj Mundraa, *, anuj.mundra87@gmail.com, Pradeep R. Deshmukha, Ajay Dawaleb
aDepartment of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, India
bDistrict Tuberculosis Office, Wardha, India
*Corresponding author at: Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sewagram 442102, Wardha, India.
Corresponding Author
Received 12 December 2016, Revised 18 February 2017, Accepted 22 February 2017, Available Online 18 March 2017.
DOI
10.1016/j.jegh.2017.02.002How to use a DOI?
Keywords
DOTS; Survival probability; Treatment adherence; Treatment outcomes
Abstract

Introduction: Deaths, defaults, relapses, and treatment failures have made the control of TB difficult across the globe.

Methodology: This study is a record-based follow-up of a cohort of patients registered under Revised National Tuberculosis Control Program in the year 2014 in Wardha Tuberculosis Unit, India. Data was collected from the records available at the District Tuberculosis Office.

Results: Data of 510 patients was analyzed. The sputum conversion rate was 88%. The overall treatment success rate was 81.9%, and rates of any adverse outcome, deaths, defaults, failure, and shift to Category IV regimen were 32.60/100 person years at risk (PYAR), 16.88/100 PYAR, 11.12/100 PYAR, 3.45/100 PYAR, and 1.15/100 PYAR, respectively. The median times for the above outcomes were 81 days, 110 days, 66 days, 118 days, and 237 days, respectively. The cumulative probability of occurrence at 6 months of any adverse outcome, deaths, default, failure, and shift to Category IV regimen was 0.145, 0.056, 0.088, 0.002, and 0.004, respectively. On multivariate analysis, the determinant of any adverse outcome was age >45 years, whereas extrapulmonary disease was protective. The hazard of defaulting was also significantly higher in male patients and those aged >45 years.

Conclusion: Appropriate interventions and program implementation to reduce the adverse treatment outcomes and interruptions will help in improving program performance.

Copyright
© 2017 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Journal of Epidemiology and Global Health
Volume-Issue
7 - 2
Pages
111 - 118
Publication Date
2017/03/18
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
10.1016/j.jegh.2017.02.002How to use a DOI?
Copyright
© 2017 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Anuj Mundra
AU  - Pradeep R. Deshmukh
AU  - Ajay Dawale
PY  - 2017
DA  - 2017/03/18
TI  - Magnitude and determinants of adverse treatment outcomes among tuberculosis patients registered under Revised National Tuberculosis Control Program in a Tuberculosis Unit, Wardha, Central India: A record-based cohort study
JO  - Journal of Epidemiology and Global Health
SP  - 111
EP  - 118
VL  - 7
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2017.02.002
DO  - 10.1016/j.jegh.2017.02.002
ID  - Mundra2017
ER  -