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2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitril(7) is an important intermediate in many PI3K/mTOR inhibitors. The compound 5 was synthesized from 6-bromoquinolin-4-ol (1) and 2-(4-nitrophenyl)acetonitrile(4) through five steps including nitration, chlorination, alkylation, reduction...

7-(Benzyloxy)-4-chloro-6-methoxyquinazoline(1) was synthesized from methyl 4-hydroxy-3-methoxybenzoate(2) through five steps including substitution,nitration,reduction,cyclization and chlorination.Its structure was confirmed by 1 H NMR and MS spectrum.The total yield of the five steps was 29.2%.

According to university education status quo of weak social innovation, combined with college students thinking ability and knowledge, proposed financing social innovation in everyday teaching philosophy, mainly through everyday teaching continue to integrate into innovative ideas, research and innovation...

Discretization of the basic-shape areas is described in the paper. Using Multi-axial spring model (called MS model) or fiber model for structural member idealization, the critical sections of the member are discretized in to a number of small elements (represented by springs or fibers) according to the...

In this experiment, we studied the effects of astaxanthin on the growth and resistance of strawberry tissue culture seedlings under the stress of heavy metal cadmium. Strawberry seedlings were planted in MS medium supplemented with different concentrations of astaxanthin and with 25 mg/L GdCl2. The results...

Cohesion and coherence are essential elements that have a role in forming structural coherence and coherence of the meaning of discourse texts. The formation of a coherent structure and semantic relationship cannot be separated from using the correct elements of cohesion and coherence, which are marked...

With a focus on complex environments, the present paper describes a new algorithm in scale changed object tracking through color feature. Mean shift (MS) iterative procedure is the best color-based algorithm to find the location of an object. The algorithm performance is not acceptable once tracking...

Thin films of FeCoB-O were deposited by reactive magnetron sputtering in a Ar + O2 atmosphere with the oxygen partial pressure RO2 varied. The dependence of soft magnetic properties and high frequency characteristics on oxygen partial pressure were investigated systematically. With the increase in RO2...

Borehole instability is one of the most complex downhole problems in the drilling process. In order to study the micro-mechanism of inorganic salts on shale hydration, a micro-crystal structure model of Na-montmorillonite was established using the MS software. The shale hydration mechanism, mechanical...

Technological developments cause manga not only in print but also in digital form (デジタル漫画) and in the form of videos which are often called mangadouga (漫画動画). The development of manga can indirectly trigger manga to be more widely known and attract interest in learning Japanese. Manga as a cultural reflection...

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating advanced diagnostic tools that provide high accuracy and efficiency. This paper introduces a novel framework, the “Gorilla Troops Optimization-based Convolutional Neural Network (GTO-CNN) for Lung Cancer...

Reference is deixis following the context of the language so that it always changes and appears in various situations and language events, resulting in the meaning of the reference in one lingual unit being different. This study examines the form of person and time deixis and their forms of reference...

A novel sample treatment, namely vortex-assisted dispersive liquid-liquid microextraction (VDLLME), followed by GC/MS has been developed for the determination of gaseous phase polycyclic aromatic hydrocarbons (PAHs) emitted from a marine diesel engine. The method integrates extraction, enrichment, and...

Cloud manufacturing resource virtualization is the basis for cloud manufacturing services to be carried out, where resource virtualization aggregation is an important way to improve the efficiency of subsequent resource allocation and scheduling. However, current resource aggregation methods mostly construct...

In view of the draw backs of apple grade identification in China, which still relies on photoelectric sorting and manual separation, this paper presents a processing method on the basis of the technology of computer vision and digital image.Utilizing image processing technology, the researcher calculated...

The Internet of Medical Things (IoMT) generates continuous streams of highly sensitive patient data that demand both strong confidentiality and real-time tamper detection during transmission and cloud storage. Traditional encryption algorithms such as AES and RSA provide strong security but are computationally...

The quantitative determination method of seven organic phosphate esters (OPEs) in urine by gas chromatography-mass spectrometry was established and optimized by changing the derivative reaction procedure, the different sample doses and the different extraction reagents. The results showed that the best...

Bromo-Tengger-Semeru National Park is the location where "Tengger" ethnic people live. The Tengger ethnic people are mostly farmers around the protected forest area. This study aims to understand the Tengger ethnic community in conserving the forests based on local wisdom "Sesanti Panca Setya" or ”sesanti...

Corruption is a serious problem for countries in the world because it has a big negative impact on society. Various efforts have been made to prevent the danger of corruption, one of which is by building an anti-corruption culture in schools through the planting of anti-corruption character values integrated...

The practice of early marriage has been banned in international agreements because of the many negative impacts in terms of health, economy and psychology for mothers and children. But the practice of early marriage was still going on with different patterns between one region and another. The focus...

The growth of Location Based Services and Location Aware Services in indoor environments has focused the attention of the research community on indoor location systems, especially on those based on WLAN networks and Received Signal Strength (RSS). Despite the advances reached, the development of reliable,...

Family harmony has a significant relationship with children development, as well as gambling family. The focus of this paper examines the development of children in gambling families. The research design used is phenomenology with an analysis that refers to the perspective of Creswell. Data obtained...

Body has an important meaning for commercial sex workers (CSWs). The body becomes the main capital to attract and attract customers. Having a beautiful and awake body is a special attraction to maintain existence in the world of prostitution. The focus of this study describes the pattern of body care...

Sexual behavior is considered as contemporary activities and become part of adolescence lifestyle. The substance of this study is reveals the meaning of sexual behavior in the students of university perspective. The research design used was interpretive by referring to George H. Mead's symbolic interactionism...

Sexual abuse towards children may cause psychological, physical, and social trauma. This study focuses on self-recovery attempts of victims after being sexually abused. Phenomenology design referring to Creswell perspective as knife analysis was utilized. The data were obtained by doing an in-depth interview...

In order to study the effects of mass ratio of steam to biomass (mS/mB) and temperature on the gas composition, a model was developed to simulate the biomass-steam gasification process using Fluent in a fluidized bed. The simulated results showed that the volume fraction of H2 increased firstly and then...

Beggar is a social problem that is difficult to overcome in Jombang and Mojokerto districts. Begging activity is often used as a profession because it produces profits. The focus of this research is to find out how the beggar strategies in getting donations. This paper uses phenomenological design with...

Klitih is a form of juvenile delinquency by fighting, throwing stones, injuring and even killing victims in Yogyakarta. Various attempts have been made by the government, educational institutions and the police to overcome them. This paper discusses the strategy of Geng Klithih in avoiding police capture....

Street children are a serious problem in Surabaya. Loss of educational rights, involved in crime, promiscuity and susceptible to drugs. The study aims to find a role of Kampung Anak Negeri for the transformation process towards normal life. This case study research uses Talcott Parson's functional structural...

Globalization opens the way for the entry of foreign values and cultures that can be a threat to the identity of the Indonesian nation, especially for the younger generation. Multicultural based Pancasila education is important for young people to strengthen Indonesian identity. This study aims to analyze...

The process of forming a Japanese word is called gokeisei. Gokeisei consists of 4 kinds, namely haseigo (派生語), karikomi or shouryaku (刈り込み· 省略), toujigo (頭字語) and fukugougo/gouseigo (複合語· 合成語). This study aims to identify changes in phonemes in the process of gouseigo formation. In this study, the data...

Teaching materials are important elements in the achievement of learning objectives, including anti-corruption education. In order to ensure the quality of teaching materials, researchers conducted a trial of the feasibility of teaching materials that have been developed regarding anti-corruption education...

Beggars become a social problem in Situbondo. Poverty is the main reason for begging. Not infrequently they settled on the streets because they do not have a place to stay. Based on the paradigm of the functional structure of the focus of research illustrates how beggars sought shelter and assistance...

This study derives from an issue of information ambiguity that became a polemic in the community due to the false information posted on Instagram by MSGLOW. The public claimed that this brand deceived them by stating that it would participate in The Paris Fashion Week event while it only participated...

The community tends to have negative perceptions towards widowhood which leads to discriminatory treatments. The focus of this study illustrates the strategy of young widows in the District of Sukun in Malang City to strive in their social environment. The design of this research was phenomenology with...

Planting the soul of nationalism is important starting from the beginning to deal with the erosion of national identity along with the process of globalization. One effort to build the spirit of nationalism can be done through internalizing the value of didactic morality and patriotism in the learning...

Schumann's Song Cycle "Women in Love and Life" has high artistic value and rich content. Articles from romantic art features, a variety of emotional features, aesthetic features and formal beauty of the tragic features and other aspects of "women love and life" artistic characteristics were analyzed...

Street racing became a teenager trend in Pasuruan East Java Indonesia, although accidents often come to pass but do not dampen the spirit of teenagers in street racing competition. The focus in this articles analyze significance of winning and how to get it in the street racing arena. The research design...

Education personnel are Human Resources who have an important role to support the performance of academics, who are obliged to provide academic services. In carrying out its duties, can not be separated from the existence of interdependence and even the relationship between one unit to another unit....

This research aims to develop an integrated thematic learning model based on Banyuwangi local culture for the development of elementary school students' character. A developmental research by using the Analysis, Design, Development, Implementation and Evaluation model is undertaken. The results of this...

Cheating a serious problem in the married life and the lives of social. Many impacts negati ve can arise due to the behavior of infidelity. The focus of the problem in this paper is the strategy of rural women infidelity that occurred in Trenggulunan Village, Ngasem District, Bojonegoro Regency. The...

The monitoring of halo hydrocarbons such as R134a in atmosphere has attract great attention due to its strong global warming effect. In this study, on-line atmospheric pressure ionization (API) and electron impact ionization (EI) mass spectroscopy was used to measure R134a at ambient level (ppt, 10-12...

This article analyze the implementation of Green Supply Chain Management (GSCM) on competitiveness, environmental performance and food and beverage SMEs performance in Pasuruan. This study aims to determine how significant GSCM implementation to competitiveness, environmental performance, and SMEs performance....

This study aims to find out the lecturers’ competitive advantages in five universities (public and private). This study employed a qualitative approach by applying a descriptive method. The instrument in this study was the researcher as the main instrument. Data were collected through interviews, observations,...

In this paper, the target pollutant, safranine T (ST) was rapidly degenerated by electrochemical polymerization method. Kinetic degradation behaviors and intermediates were also explored by various characteristic techniques. The results showed that the decolorization of ST by electrochemical oxidation...

In this paper brilliant green (BG) was decolorized by electrochemical oxidation. Kinetics and Intermediates were also studied. The results showed that the decolorization of BG by electrochemical oxidation was fitted to pseudo first-order reactions. Activation energy was 34.9 kJ/mol. HPLC –MS results...

This paper explains the role of mental models in understanding the concept of physics vector. This research type is empirical research by analyzing data from individual thinking and interview with 2 high school students. Each student represents each category (High and Low). Subjects in this study were...

The purpose of this study was to analyze comparison of socio-economic conditions of local and /migrant fishermen on the Arafura coast. The research result could be a reference knowledge and give the proper approach in empowering and managing coastal communities. The research method used descriptive statistical...

Vast amounts of data is collected into flow measurement system for the primary purpose of trade settlement, the fairness and justice of entire trade settlement system depends entirely on the integrity of the flow integrating system. Therefore, the role of flow integrating system is very important. Measurement...

This study aims to describe the ability to understand the narrative text of Indonesian Language and Literature students in the second semester. This research was conducted at the University of Musamus Merauke. Based on the observations during the lecture, it was found that Indonesian Language and Literature...