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Conference Abstract

8.5 HEMODYNAMICS DURING INTRA- AND INTERDIALYTIC PERIODS DEPEND ON ULTRAFILTRATION VOLUME

Christopher Mayer, Stephan Geilert, Julia Matschkal, Uwe Heemann, Marcus Baumann, Christoph Schmaderer
Pages: 66 - 66
Introduction: Parameters of arterial stiffness are independent cardiovascular risk factors for end-stage renal disease patients. Significant changes of these parameters between intra- and interdialytic periods have been reported previously [1]. The aim of this cross-sectional study is to describe the...
Research Article

Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry

Jonathan Vappou, Jianwen Luo, Kazue Okajima, Marco Di Tullio, Elisa Konofagou
Pages: 65 - 71
Background: Arterial stiffness is a well-established indicator of cardiovascular disease outcome. Pulse Wave Velocity (PWV) is a surrogate for arterial stiffness that is measured either globally using carotid-to-femoral applanation tonometry or locally using biomedical imaging methods. Pulse Wave Imaging...
Conference Abstract

8.1 ARTERIAL STIFFNESS, BLOOD PRESSURE AND CARDIAC OUTPUT STUDY

Suzanne Holewijn, Erik Groot Jebbink, Wim Aengevaeren, Jasper Martens, Marcel Hovens, Michel Reijnen
Pages: 65 - 65
We are planning a prospective study in 200 patients with an abdominal artery aneurysm (AAA). Non-invasive measurements will be performed including tonometry-based pulse wave analysis (PWA) and pulse wave velocity (PWV), echocardiography, and 24-hour blood pressure measurements. This study will provide...
Conference Abstract

7.10 AORTIC STIFFNESS AND BODY MASS INDEX (BMI) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Nichola Gale, Ali Albarrati, Margaret Munnery, Dennis Shale, John Cockcroft
Pages: 64 - 65
Background: Patients with COPD have increased Cardiovascular (CV) risk and commonly present with altered body composition. Patients with COPD and a low BMI have poorer health outcomes1, while obesity may increase CV risk2. The aim of this analysis was to explore BMI, CV risk, exercise capacity and systemic...
Conference Abstract

ASSOCIATION OF PULSE WAVE VELOCITY AND BODY MASS INDEX IN HEALTHY MEXICAN POPULATION

Daniela Avila Novoa, M. Cárdenas, E.G. Cardona, D. Cardona, F. Grover, C. Ramos, J. Trujillo
Pages: 64 - 64
Rational: Cardiovascular diseases represent the main cause of morbidity and mortality throughout the world (1). Arterial stiffness has shown to be an important predictor of cardiovascular events, and pulse wave velocity (PWV) is a marker of subclinical organ damage which can be measured by different...
Conference Abstract

7.7 THE EFFECT OF MARINE N-3 POLYUNSATURATED FATTY ACIDS ON CARDIAC AUTONOMIC AND HEMODYNAMIC FUNCTION IN PATIENTS WITH PSORIATIC ARTHRITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Salome Kristensen, Erik Berg Schmiddt, Annette Schlemmer, Claus Rasmussen, Esther Lindgreen, Martin Berg Johansen, Jeppe Hagstrup Christensen
Pages: 64 - 64
Background: Patients with psoriatic arthritis are at high cardiovascular risk. Marine n-3 polyunsaturated fatty acids (PUFA) may reduce the incidence of cardiovascular disease. The aim of this study was to investigate the effect of marine n-3 PUFA on cardiac autonomic function and vascular function in...
Review Article

Stiff vessels approached in a flexible way: Advancing quantification and interpretation of arterial stiffness☆

Bart Spronck
Pages: 63 - 68
Introduction: Although pulse wave velocity (PWV), a proxy of arterial stiffness, is a strong predictor of cardiovascular complications, it is confounded by blood pressure (BP) and heart rate at the time of examination. Furthermore, establishing whether an artery behaves stiffer or less stiff does not...
Conference Abstract

P7 THE URINARY PEPTIDOMIC SIGNATURE OF AORTIC STIFFNESS REVEALS MOLECULAR PATHWAYS AND DRUG TARGETS

Zhen-Yu Zhang, Makis Izoidakis, Wen-Yi Yang, Lutgarde Thijs, Fang-Fei Wei, Qi-Fang Huang, Joost Schanstra, Jens-Uwe Voigt, Tatiana Kuznetsova, Peter Verhamme, Antonia Vlahou, Harald Mischak, Jan Staessen
Pages: 63 - 63
Background: Molecular pathways leading to stiffening of the central arteries are poorly understood. We searched for differentially expressed proteins by urinary peptidomic analysis in patients with arterial stiffness and healthy controls in a case–control study. Methods: To identify urinary peptides...
Conference Abstract

VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Negoita Madalina, Manisty Charlotte, Bhuva Anish, Hughes Alun, Parker Kim, Khir Ashraf
Pages: 62 - 62
Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity...
Conference Abstract

7.1 THE DETRIMENTAL EFFECTS OF LIVE FIREFIGHTING ON ARTERIAL FUNCTION IN FIREFIGHTERS

Alexander Rosenberg, Kanokwan Bunsawat, Tommy Wee, Tracy Baynard, Gavin Horn, Denise Smith, Bo Fernhall
Pages: 62 - 62
Background: Aging is associated with increased arterial stiffness and wave reflection, which is predictive of all-cause cardiovascular (CV) mortality (1–3). Firefighters have the highest cardiovascular mortality of any occupational group (4). High levels of heat stress, physical exertion, and elevated...
Conference Abstract

6.8 THE RELATIONSHIP BETWEEN DIASTOLIC FUNCTION AND CENTRAL HEMODYNAMICS IN DIABETIC HYPERTENSIVE PATIENTS

Davide Agnoletti, Filippo Valbusa, Ari Lieber, Guido Arcaro, Michel Safar, Jacques Blacher
Pages: 61 - 61
Background: Diabetic hypertensives patients present different hemodynamic pattern than only hypertensive patients. We aimed to investigate the relationship between the diastolic function and the pulse pressure amplification (PPA), an index combining both arterial stiffness and wave reflexion, in diabetic...
Conference Abstract

5.6 LONGITUDINAL FOLLOW-UP OF ARTERIAL STIFFNESS IN PATIENTS WITH SEVERE PSORIASIS TREATED BY ANTI-IL12/IL-23 COMPARED TO ANTI-TNF ALPHA

Hakim Khettab, Manuelle Viguier, Idir Hamdidouche, Hervé Bachelez, Pierre Boutouyrie
Pages: 61 - 61
Patients with chronic severe psoriasis are at increased cardiovascular risk (CVR). Modern systemic treatments of psoriasis involve anti-TNF alpha (ATNF) and more recently introduced anti-IL12/IL-23 (ustekinumab, AIL12/23) which, by interfering with IL-17, a possibly vasculoprotective cytokine, may increase...
Research Article

The effects of central arterial pressure and autonomic dysfunction on elevations in N-terminal pro-B-type natriuretic peptide (NT-proBNP) in men with diabetes

S. Bunce, A. Stride, C. Matthews, S. Shaw, J.C. Smith
Pages: 60 - 66
Background: In diabetes, left ventricular dysfunction independent of coronary disease is common and is associated with elevations in NT-proBNP. Our aims were to determine the relative importance of central aortic pressure, cardiovascular autonomic function and arterial stiffness as predictors of elevated...
Conference Abstract

6.6 AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

Ekaterina Starostina, Elena Troitskaya, Yulia Kotovskaya, Zhanna Kobalava
Pages: 60 - 61
Background: Patients with type 2 diabetes have a high risk of CVD. Arterial stiffness gradient is a new prognostic predictor of mortality previously assessed only in dialysis population1–2. The aim of the study was to assess arterial stiffness and stiffness gradient in diabetic patients with arterial...
Conference Abstract

6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS

Ilona Hegyi, Terez Szabo, Eszter Szele, Istvan Vasas
Pages: 60 - 60
Background: In patient with type 2 diabetes mellitus (T2DM) the atherosclerosis apper in younger age, in both gender and the cardiovascular risk is much higher. The aim of our study was to examine the association between pulse wave velocity (PWV) and glycated haemoglobin (HbA1c) and low density lipoprotein...
Conference Abstract

5.4 EFFECT OF ACUTE RESISTANCE EXERCISE ON ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: DOES SEX MATTER?

Alexander Rosenberg, Tommy Wee, Elizabeth Schroeder, Kanokwan Bunsawat, Georgios Grigoriadis, Garett Griffith, Bo Fernhall, Tracy Baynard
Pages: 59 - 60
High-intensity resistance exercise (RE) acutely increases arterial stiffness and blood pressure (BP), coupled with reduced cerebral blood flow velocity (CBFv) and greater flow pulsatility in the cerebral circulation, which may be detrimental to cerebral microvasculature. Because females have different...
Conference Abstract

6.3 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOW-DENSITY NON-CALCIFIED CORONARY PLAQUES IN PATIENTS WITH TYPE 2 DIABETES AND HEALTHY CONTROLS

Kristian L. Funck, Esben Laugesen, Kristian Oevrehus, Jesper M. Jensen, Bjarne L. Noergaard, Damini Dey, Troels K. Hansen, Per L. Poulsen
Pages: 59 - 60
Background: Arterial stiffness may provide non-invasive information about cardiovascular risk in patients with type 2 diabetes. We investigated the association between arterial stiffness and subclinical coronary atherosclerosis in patients with type 2 diabetes and healthy controls. Methods: Patients...
Conference Abstract

6.2 IMPACT OF DIABETES ON ARTERIAL STIFFNESS

Rogerio Toshiro Passos Okawa, Jorge Juarez Vieira Teixeira, Alex Cardoso Perez, Eigi Wilton de Souza, Giovanna Chiqueto Duarte, Guilherme Norio Hayakawa, Lorena Lima Gargaro, Marina Franciscon Gomes da Cruz, Michel Lima Moro Alves, Milene Cripa Pizatto de Araujo, Patrick Sadao Nishikawa, Rafaela Pelisson Regla, Rafael Campos do Nascimento
Pages: 59 - 59
Objectives/Background: The purpose of our study was to examine the impact of diabetes on arterial stiffness. A systematic review, published by Cecelja and Chowienczyk (1), describes that pulse wave velocity (PWV), is highly predictive of cardiovascular events, and PWV is associated with age and blood-pressure,...
Proceedings Article

Hypoglycemic and Hypolipidemic Effects of Melastoma dodecandrum ethanol-extract on Type 2 Diabetic Rats

Chang-Lei Li, Bao-Miao Ma, Xiao-Qing Chen, Yu-Wei Liu, Xi-Ji Shu
Abstract. To observe hypoglycemic and hypolipidemic effects of Melastoma dodecandrum ethanol-extract on type 2 diabetic rats. Except twelve SPF SD rats were as the control group, the rest eighty type 2 diabetic rats were induced by feeding with high-fat and high-sugar diet and intraperitoneal injection...
Research Article

Effects of a Personalized Physical Exercise Program in the Arterial Stiffness in Older Adults

Telmo Pereira, Fabiana Santos, Inês Cipriano
Pages: 57 - 64
Introduction: This study was aimed at evaluating the effect of a tailored exercise intervention programme in the Arterial Stiffness (AS) of old adults. Methods: Non-randomized intervention study, enrolling 32 community dwelling old adults, aged over 65 years (mean age: 83.28 ± 8.29 years), with no prior...
Research Article

Quantification of arterial wall inhomogeneity size, distribution, and modulus contrast using FSI numerical pulse wave propagation

Danial Shahmirzadi, Elisa E. Konofagou
Pages: 57 - 65
Changes in aortic wall material properties, such as stiffness, have been shown to accompany onset and progression of various cardiovascular pathologies. Pulse Wave velocity (PWV) and propagation along the aortic wall have been shown to depend on the wall stiffness (i.e. stiffer the wall, higher the PWV),...
Conference Abstract

5.4 HIGH PWV IS ASSOCIATED WITH NANO-SCALE CHANGES IN THE MEDIAL LAYER OF THE INTERNAL MAMMARY ARTERY

Riaz Akhtar, Zhuo Chang, Maria Lyck Hansen, Lars Melholt Rasmussen
Pages: 57 - 57
Background: Arterial stiffening occurs as part of the natural ageing process. Degradation of the extracellular matrix (ECM) in the medial layer is typically implicated in arterial stiffening. However, little is known about how localised changes in arteries in terms of both structure and mechanical properties...
Conference Abstract

4.5 THE EFFECT OF LUNG FUNCTION ON BLOOD PRESSURE AND VASCULAR INDICES FROM ADOLESCENCE TO EARLY ADULTHOOD IN A MULTI-ETHNIC COHORT

Yao Lu, Harding Seeromanie
Pages: 57 - 57
Given the significance of lung function (LF) for vascular health in adulthood, there are surprisingly few studies that have examined the interrelationships of their developmental trajectories. Both develop and decline over the life course, though LF peaks in the 20s, and both predict cardiovascular events...
Conference Abstract

5.3 REVERSIBILITY OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION: SYSTEMATIC REVIEW AND META-ANALYSIS

Aboubacar Sidibe, Catherine Fortier, Marie-Pier Desjardins, Fabrice Mac-Way, Sacha De Serres, Mohsen Agharazii
Pages: 57 - 57
Background: Chronic kidney disease is associated with increased arterial stiffness. Correction of the uremic milieu by kidney transplantation (KTx) may be improve arterial stiffness. However, results from clinical studies are not uniformly convincing. This could be related to small sample size of studies,...
Conference Abstract

4.1 PILOT STUDY ON THE PRECLINICAL VASCULAR DAMAGE IN BOLIVIAN PATIENTS WITH CHAGAS INDETERMINATE CHRONIC PHASE

Filippo Valbusa, Andrea Angheben, Verena Zerbato, Andrea Chiampan, Davide Agnoletti, Cristiano Fava, Zeno Bisoffi, Guido Arcaro
Pages: 56 - 56
Background: In Italy, the prevalence of seropositivity for Trypanosoma cruzi in immigrants from endemic countries is about 11.3% (30.7% for Bolivian immigrants). The disease acute phase is usually asymptomatic, often leading to chronic infection that may remain silent for life (chronic indeterminate...
Conference Abstract

4.7 MEASUREMENT OF ARTERIAL STIFFNESS USING A CONNECTED BATHROOM SCALE: CALIBRATION AGAINST SPHYGMOCOR

Pierre Boutouyrie, Hakim Khettab, David Campo, Roger Yu, Nadine Buard
Pages: 56 - 56
Background: Measurement of arterial stiffness (AS) is still considered difficult. We developed a non-invasive technique to assess AS from a connected bathroom scale, based on ballistocardiography (BCG) and impedance plethysmography (IPG). Methods: We included 198 subjects and patients, 111 for calibration...
Conference Abstract

3.7 CHANGES OF INTRINSIC STIFFNESS OF THE CAROTID ARTERIAL WALL DURING THE CARDIAC CYCLE MEASURED BY SHEAR WAVE ELASTOGRAPHY IN HYPERTENSIVES COMPARED TO NORMOTENSIVES

Louise Marais, Mathieu Pernot, Hakim Khettab, Michael Tanter, Emmanuel Messas, Mustapha Zidi, Stéphane Laurent, Pierre Boutouyrie
Pages: 55 - 55
Objective: Because measurement of arterial stiffness is highly dependent on blood pressure (BP), methods independent of BP are required. Shear wave elastography (SWE, Supersonic Imagine, Aix-en-Provence, France) enables to assess local tissue stiffness by tracking the propagation of shear waves generated...
Proceedings Article

Effect of TiH2 Particle Size on Aluminum foam Pore Structure

Zhiqiang Guo, Donghui Ma, Xiaoguang Yuan, Xue Dong
Pore structures and aluminum foam densities are strongly influenced by the particle size of TiH2 powders. In this paper, TG curves of the the original powders and the 4 kinds of powders which were separaed by the original powders were researched. The foaming process and pore structures using selected...
Research Article

Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

Jitka Seidlerová, Jan Filipovský, Otto Mayer, Renata Cífková, Martin Pešta, Radek Blatný, Jiří Vaněk
Pages: 54 - 59
Background: Recently, rs3918226 polymorphism in the promoter region of endothelial NO synthase (eNOS) was strongly associated with arterial hypertension in a large genome-wide association study. We investigated whether this polymorphism was associated with arterial phenotypes in a Czech general population. Methods:...
Conference Abstract

3.5 HEART RATE DEPENDENCE OF REGIONAL AND LOCAL AORTIC PULSE WAVE VELOCITY IN RATS AS A FUNCTION OF BLOOD PRESSURE

Bart Spronck, Isabella Tan, Koen Reesink, Dana Georgevsky, Tammo Delhaas, Alberto Avolio, Mark Butlin
Pages: 54 - 54
Background: Pulse wave velocity (PWV) is quantified by time difference of arrival of the blood pressure (BP) wave at two sites along the arterial bed (transit time; TT-PWV), or by combining measured arterial pressure and diameter using the Bramwell-Hill equation (BH-PWV). Besides the dependence of PWV...
Conference Abstract

4.3 ELECTRONIC CIGARETTE SMOKING INCREASES AORTIC STIFFNESS IN YOUNG SMOKERS

Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Mahmud Abdelrasoul, Christos Georgakopoulos, Panagiota Pietri, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 54 - 54
Purpose/Background/Objectives: Smoking increases aortic stiffness which is an important predictor of cardiovascular risk. Electronic cigarettes (EC) simulate tobacco cigarette (TC) and have been advocated as a less harmful alternative. We investigated the acute effect of EC smoking on aortic stiffness...

Correlation of Blood Lipid Profile, Blood Lipid Ratio and Cystatin C in Patients with Hyperthyroidism

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang
To investigate the correlation among serum lipids and their ratios and cystatin C (CysC) in patients with hyperthyroidism. authors respectively chose fifty patients of hyperthyroidism, subclinical hyperthyroidism and the control group. TC, TG and LDL-C in the hyperthyroidism and subclinical hyperthyroidism...
Conference Abstract

4.1 TNF- ANTAGONISTS IMPROVE ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A META-ANALYSIS

Georgios Georgiopoulos, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Gravos, Panagiota Pietri, Christos Georgakopoulos, Kimon Stamatelopoulos, Dimitrios Tousoulis
Pages: 53 - 54
Purpose/Background/Objectives: Patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and an increased inflammatory burden that might be associated with their increased cardiovascular risk. Tumor necrosis factor alpha (TNF)-antagonists have...
Conference Abstract

3.2 ASCENDING AND DESCENDING AORTA PULSE WAVE VELOCITY AND DISTENSIBILITY IN BICUSPID AORTIC VALVE PATIENTS

Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Nicolas Villalva, Filipa Valente, Laura Galian, Marina Huguet, Laura Gutierrez, Teresa Gonzalez, Ruben Fernandez, Augusto Sao-Aviles, David Garcia-Dorado, Artur Evangelista
Pages: 53 - 53
Purpose: Bicuspid aortic valve (BAV) is a cardiac congenital disease associated with ascending aorta (AAo) dilation. The study of the impact of aortic biomechanics in this population has been limited by technical difficulties. Contrasting results have been reported for distensibility while studies including...
Research Article

Oxidative stress and arterial stiffness in strength- and endurance-trained athletes

Youngju Choi, Seiji Maeda, Takeshi Otsuki, Asako Miyaki, Nobutake Shimojo, Mutsuko Yoshizawa, Hitoshi Shiraki, Ryuichi Ajisaka
Pages: 52 - 58
Background: Endurance exercise training decreases arterial stiffness, whereas high-intensity strength exercise training increases arterial stiffness. However, the mechanisms underlying the adaptations to the 2 types of exercise training remain unclear. Increased oxidative stress induces vasoconstriction...
Conference Abstract

3.8 CAN ARTERIAL WAVE AUGMENTATION IN YOUNG ADULTS EXPLAIN VARIABILITY OF CARDIOVASCULAR RISK IN ETHNIC MINORITIES?

Luca Faconti
Pages: 52 - 53
Objective: Traditional cardiovascular (CV) risk factors do not fully explain ethnic differences in CV disease [1,2]. We tested if pulse wave velocity (PWV) and Augmentation Index (AIx) and their determinants from childhood may underlie ethnic variability in CV risk as young adults in the ‘DASH’ longitudinal...
Conference Abstract

3.1 INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE: A NEW OPPORTUNITY FOR CARDIOVASCULAR RISK STRATIFICATION. FIRST RESULTS ON CHRONIC KIDNEY DISEASE PATIENTS

János Nemcsik, Orsolya Cseprekál, Ádám Tabák, Dóra Batta, József Egresits, István Kiss, András Tislér
Pages: 52 - 53
Background: The evaluation of arterial stiffness and central haemodynamics represent a new tool of cardiovascular (CV) risk stratification. Our aim was to create an integrated central pressure-stiffness risk score (ICPS score) which incorporate the predictive potential of identical parameters. Methods:...
Conference Abstract

3.7 ARTERIAL STIFFNESS FOR THE EARLY PREDICTION OF PRE-ECLAMPSIA COMPARED WITH CLINICAL CHARACTERISTICS, UTERINE ARTERY DOPPLER INDICES, AND ANGIOGENIC BIOMARKERS

Kim Phan, Yessica Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella Daskalopoulou
Pages: 52 - 52
Objective: To develop a model for the 1st trimester prediction of pre-eclampsia. Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited and arterial stiffness was measured using applanation tonometry (SphygmoCor, AtCor) and compared between women who...
Conference Abstract

3.5 NON-INVASIVE US-BASED WAVE INTENSITY ANALYSIS IN MICE

Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesca Lenzarini, Francesco Faita
Pages: 52 - 52
Wave Intensity Analysis (WIA) can provide information about the interaction between vascular and cardiac system. WIA-derived indexes have quantitative physiological meaning. We investigated age-associated changes in WIA-derived parameters in mice and correlated them with biomarkers of cardiac function. Sixteen...
Proceedings Article

RBF Prediction Model Based on EMD for Forecasting GPS Precipitable Water Vapor and Annual Precipitation

Yanping Liu, Yong Wang, Zhen Wang
The forecast of precipitations is important in meteorology and atmospheric sciences. A new model is proposed based on empirical mode decomposition and the RBF neural network. Firstly, GPS PWV time series is broken down into series of different scales intrinsic mode function. Secondly, the phase-space...
Conference Abstract

2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS

Matthew K. Armstrong, Martin G. Schultz, Dean S. Picone, James E. Sharman
Pages: 51 - 52
Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among...
Conference Abstract

2.4 BRACHIAL CUFF RESERVOIR CHARACTERISTICS AND END-ORGAN MARKERS OF CARDIOVASCULAR RISK IN AUSTRALIAN ADULTS: A CROSS-SECTIONAL STUDY

Xiaoqing Peng, Martin Schultz, Michael Cheung, Melissa Wake, Jonathan Mynard, David Burgner, Richard Liu, James Sharman
Pages: 51 - 51
Objective: Reservoir-excess pressure measured using tonometry methods predicts cardiovascular events, but the operator-dependency of tonometry is an impediment to widespread use. A cuff-based blood pressure device has been developed to derive reservoir-excess pressure from measured brachial pressure...
Conference Abstract

3.1 REDUCING ARTERIAL STIFFNESS INDEPENDENTLY OF BP: PROOF OF CONCEPT? CAVI, PWV AND CARDIAC DATA IN THE 6-MONTH VASERA TRIAL

Charlotte Mills, Luca Faconti, Virginia Govoni, Steve Morant, Maria-Linda Casagrande, Haotian Gu, Benyu Jiang, Andrew Webb, Kennedy Cruickshank
Pages: 51 - 51
Purpose/ background/ objectives: People with or at risk of Type II diabetes (T2DM) are at increased risk of vascular disease and arterial stiffness (AS). We hypothesized that spironolactone and dietary nitrate (beetroot juice) separately and together would reduce AS, measured as cardiac-ankle vascular...
Conference Abstract

2.2 HEART STRUCTURE AND VASCULAR FUNCTION IN YOUNG PATIENTS AFTER ENDOVASCULAR REPAIR FOR BLUNT THORACIC AORTIC INJURY

Paola Vallerio, Ilenia D’Alessio, Alessandro Maloberti, Marisa Varrenti, Simone Maggioni, Valentina Cantu, Marco Carbonaro, Maria Cristina Ferrara, Elisa Spada, Bruno Palmieri, Alfredo Lista, Cristina Giannattasio
Pages: 50 - 50
Objective: Thoracic Endovascular Aortic Repair (TEVAR) currently represents the gold standard of treatment for Blunt Thoracic Aortic Injury (BTAI). Nevertheless, there is an ongoing debate surrounding its safety and efficacy and its subsequent CV effects. The present study is aimed at assessing heart...
Conference Abstract

2.5 THE EFFECT OF RENAL DENERVATION ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN TREATMENT RESISTANT ESSENTIAL HYPERTENSION: A SUBSTUDY OF A RANDOMIZED SHAM-CONTROLLED DOUBLE-BLINDED TRIAL (THE RESET TRIAL)

Christian D. Peters, Ole N. Mathiasen, Henrik Vase, Jesper Bech, Kent L. Christensen, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Hans E. Bøtker, Morten Engholm, Jannik B. Bertelsen, Jens F. Lassen, Erling B. Pedersen, Anne Kaltoft, Niels H. Buus
Pages: 50 - 50
Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to investigate, whether RDN affects central blood pressure...

Metabolic parameters and blood pressures achieved by diabetic patients at two health care facilities in south Trinidad

Ganga Bhagirathee, Rohan G. Maharaj
Pages: 49 - 56
Background: Previous studies have demonstrated poor metabolic and blood pressure control in the diabetic population in Trinidad. The aim of this study is to compare baseline and follow-up metabolic parameters and blood pressures taken within a 16-month period to ascertain if there have been improvements. Method:...
Research Article

Integrated Central Blood Pressure-aortic Stiffness Risk Categories and Cardiovascular Mortality in End-stage Renal Disease

Dóra Batta, Ádám Tabák, Beáta Kőrösi, Orsolya Cseprekál, József Egresits, András Tislér, János Nemcsik
Pages: 49 - 55
Background: Our aim was to study the predictive power of integrated central blood pressure-aortic stiffness (ICPS) risk categories on cardiovascular (CV) mortality in end-stage renal disease (ESRD) patients. Methods: This is a secondary analysis of a prospective study of 91 ESRD patients on hemodialysis...
Conference Abstract

2.3 DETERMINANTS OF INAPPROPRIATELY HIGH PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS: A RETROSPECTIVE CROSS-SECTIONAL COHORT STUDY

Marina Di Pilla, Rosa Maria Bruno, Simona Buralli, Melania Sgro’, Piero Amedeo Modesti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 49 - 50
Background: Age and blood pressure (BP) are known to be the main determinants of large artery stiffness. However other factors may lead to an inappropriately high pulse wave velocity (PWV). We investigated the determinants of inappropriately high PWV in hypertensive patients and their possible role in...
Conference Abstract

NAA1 NICOTINAMIDE RIBOSIDE SUPPLEMENTATION REDUCES AORTIC STIFFNESS AND BLOOD PRESSURE IN MIDDLE-AGED AND OLDER ADULTS

Christopher Martens, Blair Denman, Melissa Mazzo, Michael Armstrong, Nichole Reisdorph, Matthew McQueen, Michel Chonchol, Douglas Seals
Pages: 49 - 49
Purpose: Regular calorie restriction (CR) improves endothelial function and lowers aortic stiffness in older mice and humans; however, adherence to sustained CR remains poor, and possibly unsafe in normal weight older adults. Nicotinamide adenine dinucleotide (NAD+) is an important signaling molecule...
Research Article

Design and progress of a factorial trial testing the effect of spironolactone and inorganic nitrate on arterial function in people at risk of or with type 2 diabetes

Charlotte E. Mills, Virginia Govoni, Maria Linda Casagrande, Luca Faconti, Andrew J. Webb, J. Kennedy Cruickshank
Pages: 48 - 53
Background: Arterial stiffness (AS), as pulse wave velocity (PWV), is a powerful independent predictor of cardiovascular events and commonly complicates type 2 diabetes (T2D). This trial aims to test if AS, measured by the VaSera machine as cardio-ankle vascular index (CAVI) and by Arteriograph measuring...