Clinical Hematology International

Latest Articles

Review Article

How I Use Measurable Residual Disease in the Clinical Management of Adult Acute Lymphoblastic Leukemia

Fiona Fernando, Harry Frederick Robertson, Sarah El-Zahab, Jiří Pavlů
Volume 3, Issue 4, December 2021, Pages 130-141
Over the last decade the use of measurable residual disease (MRD) diagnostics in adult acute lymphoblastic leukemia (ALL) has expanded from a limited number of study groups in Europe and the United States to a world-wide application. In this review, we summarize the advantages and drawbacks of the current...
Research Article

The Management of a Comprehensive Cancer Center during the First Six Months of the COVID-19 Pandemic in the South of France: Lessons from the Paoli-Calmettes Institute’s Experience

Didier Blaise, Pierre Berger, Djamel Mokart, Jacques Camerlo, Emmanuelle Fougereau, Marc Giovannini, Gilles Houvenaeghel, Olivier Turrini, Christian Chabannon, Gilles Piana, Isabelle Brenot-Rossi, Agnès Tallet, Anthony Gonçalves, Aude Charbonnier, Norbert Vey, Sabrina Grossi, Patrice Viens
Volume 3, Issue 4, December 2021, Pages 119-129
During the COVID-19 pandemic, it was rapidly established that cancer patients have an increased risk of developing severe forms of the 2019 coronavirus disease (COVID-19) due to a backlog of cancer diagnostics and immunosuppressive treatments. Cancer centers had to quickly adapt to continue cancer therapies...
Research Article

Gastrointestinal Complications after Allogeneic Hematopoietic Stem Cell Transplant: A Multidisciplinary Approach with Early Endoscopic Evaluation

Giuseppe Tarantino, Francesco Saraceni, Giorgia Mancini, Monica Poiani, Luca Maroni, Gaia Goteri, Ilaria Scortechini, Alessandro Fiorentini, Maria Vittoria Dubbini, Francesco Marini, Luigi Daretti, Marco Marzioni, Emanuele Bendia, Antonio Benedetti, Attilio Olivieri
Volume 3, Issue 4, December 2021, Pages 161-168
Gastrointestinal complications (GICs) represent the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Differential diagnosis of GICs is of paramount importance since early and reliable identification of graft-versus-host disease (GVHD) is essential...
Review Article

Conditioning Regimens for Frail Patients with Acute Leukemia Undergoing Allogeneic Stem Cell Transplant: How to Strike Gently

Francesco Saraceni, Ilaria Scortechini, Alessandro Fiorentini, Maria Vittoria Dubbini, Giorgia Mancini, Irene Federici, Francesca Romana Colaneri, Antonio Federico Lotito, Selene Guerzoni, Bruna Puglisi, Attilio Olivieri
Volume 3, Issue 4, December 2021, Pages 153-160
Despite the recent dramatic progress in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) therapy, allogeneic transplant remains a mainstay of treatment for patients with acute leukemia. The availability of novel compounds and low intensity chemotherapy regimens made it possible for...
Research Article

CD3/CD19 Depletion for T-cell Reduction of Allogeneic Transplants: Mostly Efficient, but not Robust

Eliza Wiercinska, Erhard Seifried, Halvard Bonig
Volume 3, Issue 3, September 2021, Pages 103-107
Aggressive T-cell depletion, in vitro or in vivo, is a prerequisite for survival of haplo-identical stem cell transplantation. The classical T-cell-depleted transplant, immunomagnetically enriched CD34+ cells, is very safe with respect to graft-versus-host reactivity, but associated with very high transplant-related...
Research Article

High Sensitivity Troponin T and NT-proBNP in Patients Receiving Chimeric Antigen Receptor (CAR) T-Cell Therapy

Jiun-Ruey Hu, Ameet Patel, Shi Huang, Yan Ru Su, Kimberly B. Dahlman, Kelsey Tomasek, Yueli Zhang, Richard T. O’Neil, Jamye F. O’Neal, Isik Turker, Douglas B. Johnson, Joe-Elie Salem, Javid J. Moslehi, Olalekan Oluwole
Volume 3, Issue 3, September 2021, Pages 96-102
Retrospective studies suggest that chimeric antigen receptor T-cell (CAR T) therapy may lead to cardiac injury, but this has not been assessed systematically or prospectively. In this prospective study of 40 patients who received CAR T, we systematically measured high-sensitivity troponin T (hsTropT)...
Review Article

History of Acute Promyelocytic Leukemia

Miguel A. Sanz, Eva Barragán
Volume 3, Issue 4, December 2021, Pages 142-152
In this article, we discuss the history of acute promyelocytic leukemia (APL) from the pre-therapeutic era, which began after its recognition by Hillestad in 1947 as a nosological entity, to the present day. It is a paradigmatic history that has transformed the “most malignant leukemia form” into the...
Review Article

History and Development of Autologous Stem Cell Transplantation for Acute Myeloid Leukemia

Norbert Claude Gorin
Volume 3, Issue 3, September 2021, Pages 83-95
This review describes the development of cryopreservation, the birth of autologous stem cell transplantation (ASCT) and its past and present use to consolidate adult patients with acute myelogenous leukemia (AML). It summarizes the first autografts in patients in relapse, the experience of autografting...

The Impact of Achieving Complete Remission Prior to Allogeneic Stem Cell Transplantation on Progression-Free Survival in Hodgkin Lymphoma

Nadira Duraković, Zinaida Perić, Sandra Bašić Kinda, Lana Desnica, Dino Dujmović, Ivo Radman Livaja, Ranka Serventi Seiwerth, Igor Aurer, Radovan Vrhovac
Volume 3, Issue 3, September 2021, Pages 116-118
Research Article

Baseline Photos and Confident Annotation Improve Automated Detection of Cutaneous Graft-Versus-Host Disease

Xiaoqi Liu, Kelsey Parks, Inga Saknite, Tahsin Reasat, Austin D. Cronin, Lee E. Wheless, Benoit M. Dawant, Eric R. Tkaczyk
Volume 3, Issue 3, September 2021, Pages 108-115
Cutaneous erythema is used in diagnosis and response assessment of cutaneous chronic graft-versus-host disease (cGVHD). The development of objective erythema evaluation methods remains a challenge. We used a pre-trained neural network to segment cGVHD erythema by detecting changes relative to a patient’s...
Research Article

Allogeneic Stem Cell Transplantation with a Novel Reduced Intensity Conditioning Regimen for the Treatment of Patients with Primary Cutaneous T-cell Lymphomas

Maria Stamouli, Konstantinos Gkirkas, Aggeliki Karagiannidi, Theodoros Iliakis, Spiros Chondropoulos, Thomas Thomopoulos, Vassiliki Nikolaou, Vassiliki Pappa, Evangelia Papadavid, Panagiotis Tsirigotis
Volume 3, Issue 2, June 2021, Pages 72-76
The prognosis of patients with mycosis fungoides (MF) and Sezary Syndrome (SS) varies greatly, from near normal life expectancy in patients with early stage, to a median survival of less than 2 years for those diagnosed with advanced stage disease. Initial response to treatment is almost always followed...
Review Article

Therapeutic Use of Convalescent Plasma in COVID-19 Infected Patients with Concomitant Hematological Disorders

Francesco Lanza, Vanessa Agostini, Federica Monaco, Francesco Passamonti, Jerard Seghatchian
Volume 3, Issue 3, September 2021, Pages 77-82
The use of convalescent plasma (CP) from individuals recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a promising therapeutic modality for the coronavirus disease 2019 (COVID-19). CP has been in use for at least a century to provide passive immunity against a number of diseases,...
Review Article

Passive Immunity Should and Will Work for COVID-19 for Some Patients

Nevio Cimolai
Volume 3, Issue 2, June 2021, Pages 47-68
In the absence of effective antiviral chemotherapy and still in the context of emerging vaccines for severe acute respiratory syndrome-CoV-2 infections, passive immunotherapy remains a key treatment and possible prevention strategy. What might initially be conceived as a simplified donor–recipient process,...

Red Blood Cell Distribution Width: Another Prognostic Factor for COVID-19?

Maria Lagadinou, Despoina Gkentzi, Markos N. Marangos, Fotini Paliogianni, Elena E. Solomou
Volume 3, Issue 2, June 2021, Pages 69-71
The coronavirus disease 2019 (COVID-19) is a pandemic with a high rate of hospitalization, admission to intensive care units, and mortality. Identifying patients at the highest risk for severe disease is important to facilitate early, aggressive intervention. High red blood cell distribution width (RDW)...
Review Article

Polatuzumab Vedotin: Current Role and Future Applications in the Treatment of Patients with Diffuse Large B-Cell Lymphoma

Rita Assi, Nohad Masri, Iman Abou Dalle, Jean El-Cheikh, Hady Ghanem, Ali Bazarbachi
Volume 3, Issue 1, March 2021, Pages 21-26
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Despite good responses to standard of care frontline chemoimmunotherapy, the prognosis of relapsed/refractory (R/R) patients remains obscured by the possible inadequate responses to salvage therapy, eligibility...

One Year into the COVID-19 Pandemic

Mohamad Mohty, Junia V. Melo
Volume 3, Issue 1, March 2021, Pages 1-2
Research Article

Association of Patient-Reported Physical Activity on Allogeneic Hematopoietic Cell Transplant Outcomes

Reena V. Jayani, Joseph Pidala, Heather Jim, Junmin Whiting, Qianxing Mo, Asmita Mishra
Volume 3, Issue 1, March 2021, Pages 34-39
Background: Physical function prior to allogeneic hematopoietic cell transplant (HCT) is associated with survival and may be associated with patient physical activity (PA). Tools to evaluate PA prior to HCT are scarce. We aimed to evaluate the impact of easily obtained patient-report of PA prior to HCT...
Mini Review

How to Make the Right Diagnosis in Neutropenia

Elena E. Solomou, Christina Salamaliki, Maria Lagadinou
Volume 3, Issue 2, June 2021, Pages 41-46
Isolated neutropenia without anemia or thrombocytopenia is a common clinical problem. The etiology of neutropenia may vary from transient bone marrow suppression, caused by self-limited viral illnesses, to previously undiagnosed congenital syndromes or serious systemic diseases. Consequently, determining...
Research Article

How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma

Treen Carson Michael Morris, Mary B. Drake, Paul J. Kettle, Tracey McGuigan, Maeve Leahy, Michael O’Dwyer, Helen Enright, Tanya O’Shea, Rakesh Popat, Heather E. Oakervee, Kwee Yong, Jamie D. Cavenagh, David A. Cairns, Alberto Alvarez-Iglesias, Gordon Cook
Volume 3, Issue 1, March 2021, Pages 27-33
When the bortezomib [PS341], adriamycin and dexamethasone (PAD) regimen was first evaluated, the response rate in untreated patients was much superior to that elicited by conventional chemotherapeutic agents. We demonstrated the efficacy of PAD in relapsed or refractory patients by comparing the response...
Review Article

The Many Faces of Cytokine Release Syndrome-Related Coagulopathy

Jiasheng Wang, John Doran
Volume 3, Issue 1, March 2021, Pages 3-12
Cytokine release syndrome (CRS) has been increasingly recognized in various conditions including the coronavirus disease 2019 (COVID-19). It is not only associated with systemic inflammatory symptoms, but also hematological complications such as coagulopathy. CRS can affect various components of the...
Review Article

Machine Learning Applications in the Diagnosis of Benign and Malignant Hematological Diseases

Ibrahim N. Muhsen, David Shyr, Anthony D. Sung, Shahrukh K. Hashmi
Volume 3, Issue 1, March 2021, Pages 13-20
The use of machine learning (ML) and deep learning (DL) methods in hematology includes diagnostic, prognostic, and therapeutic applications. This increase is due to the improved access to ML and DL tools and the expansion of medical data. The utilization of ML remains limited in clinical practice, with...
Research Article

Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation

Sejal Morjaria, Allen W. Zhang, Sohn Kim, Jonathan U. Peled, Simone Becattini, Eric R. Littmann, Eric. G. Pamer, Michael C. Abt, Miguel-Angel Perales
Volume 2, Issue 4, December 2020, Pages 156-164
Background: Monocytes are an essential cellular component of the innate immune system that support the host’s effectiveness to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depletion, but the factors that regulate recovery of monocyte populations...
Review Article

CART Cell Toxicities: New Insight into Mechanisms and Management

Anas Zahid, Elizabeth L. Siegler, Saad S. Kenderian
Volume 2, Issue 4, December 2020, Pages 149-155
T cells genetically engineered with chimeric antigen receptors (CART) have become a potent class of cancer immunotherapeutics. Numerous clinical trials of CART cells have revealed remarkable remission rates in patients with relapsed or refractory hematologic malignancies. Despite recent clinical success,...

COVID-19 in Hematologic Malignancies: Big Challenges

Yongxian Hu, Linqin Wang, Qu Cui, Elaine Tan Su Yin, Hengwei Wu, Arnon Nagler, He Huang
Volume 2, Issue 4, December 2020, Pages 173-175
Research Article

Emicizumab Associated Rhabdomyolysis in Hemophilia A

Joseph A. Wilson, Stephanie Hayden, Alexander Asamoah, Vivek R. Sharma, David C. Jennings, Ashok B. Raj
Volume 2, Issue 4, December 2020, Pages 165-167
Emicizumab is increasingly the front-line treatment for patients with Hemophilia A with or without inhibitors. Rhabdomyolysis is a syndrome of muscle necrosis and release of intracellular muscle constituents into the circulation. Creatine kinase (CK) levels are typically markedly elevated, and muscle...